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Symptomatic VenousThromboembolism inCancer PatientsTreated WithChemotherapy Hans‐Martin OttenJoost MathijssenHugo Ten Cate2004 год

Symptomatic Venous Thromboembolism in Cancer Patients Treated With Chemotherapy
статья из журнала

Страница публикацииПубликация в OpenAlex
Аннотация: The exact incidence of venous thromboembolism (VTE) in cancer patients is unknown, partly because of confounding factors. Prophylactic treatment is warranted in surgical patients with cancer because of a high incidence of VTE. We performed a retrospective study to evaluate if the same applies for cancer patients treated with chemotherapy.The medical records of 206 consecutive patients with malignancy, treated with chemotherapy, were identified. The kind of malignancy and chemotherapeutic treatment were recorded, as was the date of treatment. The records were reviewed for other risk factors for VTE, and were searched for proved deep venous thrombosis or pulmonary embolism.Of those 206 patients, 15 (7.3%) had proved VTE during or within 3 months after chemotherapeutic treatment. The annual incidence was 10.9%. The incidence of VTE was specifically high in the 39 patients treated with a combination of fluorouracil and leucovorin calcium because of colorectal cancer (6 [15%] of the patients were affected). The occurrence of VTE in the latter group of patients was not influenced by factors such as surgery, central venous catheters, or tumor load.The annual incidence of VTE in patients treated with chemotherapy was high, specifically in patients with colorectal cancer treated with fluorouracil-leucovorin. If these observations are confirmed, trials to evaluate the use of prophylactic anticoagulant treatment should be conducted.
Год издания: 2004
Авторы: Hans‐Martin Otten, Joost Mathijssen, Hugo Ten Cate, Marcel Soesan, Marijke Inghels, Dick J. Richel, Martin H. Prins
Издательство: American Medical Association
Источник: Archives of Internal Medicine
Ключевые слова: Venous Thromboembolism Diagnosis and Management, Central Venous Catheters and Hemodialysis, Chemotherapy-related skin toxicity
Другие ссылки: Archives of Internal Medicine (HTML)
PubMed (HTML)