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Use ofcancer‐specificgenomicrearrangements toquantify diseaseburden in plasma frompatients with solidtumors David J. McBrideArto OrpanaChristos Sotiriou2010 год

Use of cancer‐specific genomic rearrangements to quantify disease burden in plasma from patients with solid tumors
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Аннотация: Abstract Detection of recurrent somatic rearrangements routinely allows monitoring of residual disease burden in leukemias, but is not used for most solid tumors. However, next‐generation sequencing now allows rapid identification of patient‐specific rearrangements in solid tumors. We mapped genomic rearrangements in three cancers and showed that PCR assays for rearrangements could detect a single copy of the tumor genome in plasma without false positives. Disease status, drug responsiveness, and incipient relapse could be serially assessed. In future, this strategy could be readily established in diagnostic laboratories, with major impact on monitoring of disease status and personalizing treatment of solid tumors. © 2010 Wiley‐Liss, Inc.
Год издания: 2010
Авторы: David J. McBride, Arto Orpana, Christos Sotiriou, Heikki Joensuu, Philip J. Stephens, Laura Mudie, Eija Hämäläinen, Lucy Stebbings, Leif C. Andersson, Adrienne M. Flanagan, Virginie Durbecq, Michail Ignatiadis, Olli Kallioniemi, Caroline A. Heckman, Kari Alitalo, Henrik Edgren, P. Andrew Futreal, Michael R. Stratton, Peter J. Campbell
Издательство: Wiley
Источник: Genes Chromosomes and Cancer
Ключевые слова: Cancer Genomics and Diagnostics, Pancreatic and Hepatic Oncology Research, Genomic variations and chromosomal abnormalities
Другие ссылки: Genes Chromosomes and Cancer (HTML)
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