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High-resolutiongenomic profiles ofhuman lung cancer Giovanni TononKwok‐Kin WongGautam Maulik2005 год

High-resolution genomic profiles of human lung cancer
статья из журнала

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Lung cancer is the leading cause of cancer mortality worldwide, yet there exists a limited view of the genetic lesions driving this disease. In this study, an integrated high-resolution survey of regional amplifications and deletions, coupled with gene-expression profiling of non-small-cell lung cancer subtypes, adenocarcinoma and squamous-cell carcinoma (SCC), identified 93 focal copy-number alterations, of which 21 span <0.5 megabases and contain a median of five genes. Whereas all known lung cancer genes/loci are contained in the dataset, most of these recurrent copy-number alterations are previously uncharacterized and include high-amplitude amplifications and homozygous deletions. Notably, despite their distinct histopathological phenotypes, adenocarcinoma and SCC genomic profiles showed a nearly complete overlap, with only one clear SCC-specific amplicon. Among the few genes residing within this amplicon and showing consistent overexpression in SCC is p63 , a known regulator of squamous-cell differentiation. Furthermore, intersection with the published pancreatic cancer comparative genomic hybridization dataset yielded, among others, two focal amplicons on 8p12 and 20q11 common to both cancer types. Integrated DNA–RNA analyses identified WHSC1L1 and TPX2 as two candidates likely targeted for amplification in both pancreatic ductal adenocarcinoma and non-small-cell lung cancer.
Год издания: 2005
Авторы: Giovanni Tonon, Kwok‐Kin Wong, Gautam Maulik, Cameron Brennan, Bin Feng, Yunyu Zhang, Deepak Khatry, Alexei Protopopov, M. James You, Andrew J. Aguirre, Eric S. Martin, Zhaohui Yang, Hongbin Ji, Lynda Chin, Ronald A. DePinho
Издательство: National Academy of Sciences
Источник: Proceedings of the National Academy of Sciences
Ключевые слова: Genomic variations and chromosomal abnormalities, Cancer Genomics and Diagnostics, Genetic factors in colorectal cancer
Другие ссылки: Proceedings of the National Academy of Sciences (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
PubMed (HTML)