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Excess risk of fatalcoronary heartdisease associatedwith diabetes in menand women:meta-analysis of 37prospective cohortstudies Rachel HuxleyFederica BarziMark Woodward2005 год

Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies
review

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Аннотация:

Abstract

Objective To estimate the relative risk for fatal coronary heart disease associated with diabetes in men and women. Design Meta-analysis of prospective cohort studies. Data sources Studies published between 1966 and March 2005, identified through Embase and Medline, using a combined text word and MESH heading search strategy, in addition to studies from the Asia Pacific Cohort Studies Collaboration. Review methods Studies were eligible if they had reported estimates of the relative risk for fatal coronary heart disease comparing men and women with and without diabetes. Studies were excluded if the estimates were not adjusted at least for age. Results 37 studies of type 2 diabetes and fatal coronary heart disease among a total of 447 064 patients were identified. The rate of fatal coronary heart disease was higher in patients with diabetes than in those without (5.4 v 1.6%). The overall summary relative risk for fatal coronary heart disease in patients with diabetes compared with no diabetes was significantly greater among women than it was among men: 3.50, 95% confidence interval 2.70 to 4.53 v 2.06, 1.81 to 2.34. After exclusion of the eight studies that had adjusted only for age, the difference in risk between the sexes was substantially reduced but still highly significant. The pooled ratio of the relative risks (women: men) from the 29 studies with multiple adjusted estimates was 1.46 (1.14 to 1.88). Conclusions The relative risk for fatal coronary heart disease associated with diabetes is 50% higher in women than it is in men. This greater excess coronary risk may be explained by more adverse cardiovascular risk profiles among women with diabetes, combined with possible disparities in treatment that favour men.
Год издания: 2005
Авторы: Rachel Huxley, Federica Barzi, Mark Woodward
Издательство: BMJ
Источник: BMJ
Ключевые слова: Cardiovascular Function and Risk Factors, Diabetes, Cardiovascular Risks, and Lipoproteins, Acute Myocardial Infarction Research
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