1. Главная
  2. Ресурсы
  3. Библиотечный поиск
Diabetic Nephropathy:Diagnosis,Prevention, andTreatment Jorge Luiz GrossMirela Jobim de AzevedoSandra Pinho Silveiro2005 год

Diabetic Nephropathy: Diagnosis, Prevention, and Treatment
review

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Diabetic nephropathy is the leading cause of kidney disease in patients starting renal replacement therapy and affects ∼40% of type 1 and type 2 diabetic patients. It increases the risk of death, mainly from cardiovascular causes, and is defined by increased urinary albumin excretion (UAE) in the absence of other renal diseases. Diabetic nephropathy is categorized into stages: microalbuminuria (UAE >20 μg/min and ≤199 μg/min) and macroalbuminuria (UAE ≥200 μg/min). Hyperglycemia, increased blood pressure levels, and genetic predisposition are the main risk factors for the development of diabetic nephropathy. Elevated serum lipids, smoking habits, and the amount and origin of dietary protein also seem to play a role as risk factors. Screening for microalbuminuria should be performed yearly, starting 5 years after diagnosis in type 1 diabetes or earlier in the presence of puberty or poor metabolic control. In patients with type 2 diabetes, screening should be performed at diagnosis and yearly thereafter. Patients with micro- and macroalbuminuria should undergo an evaluation regarding the presence of comorbid associations, especially retinopathy and macrovascular disease. Achieving the best metabolic control (A1c <7%), treating hypertension (<130/80 mmHg or <125/75 mmHg if proteinuria >1.0 g/24 h and increased serum creatinine), using drugs with blockade effect on the renin-angiotensin-aldosterone system, and treating dyslipidemia (LDL cholesterol <100 mg/dl) are effective strategies for preventing the development of microalbuminuria, in delaying the progression to more advanced stages of nephropathy and in reducing cardiovascular mortality in patients with type 1 and type 2 diabetes.
Год издания: 2005
Авторы: Jorge Luiz Gross, Mirela Jobim de Azevedo, Sandra Pinho Silveiro, Luís Henrique Santos Canani, Maria Luiza Caramori, Themis Zelmanovitz
Издательство: American Diabetes Association
Источник: Diabetes Care
Ключевые слова: Chronic Kidney Disease and Diabetes, Blood Pressure and Hypertension Studies, Renal and Vascular Pathologies
Другие ссылки: Diabetes Care (PDF)
Diabetes Care (HTML)
CiteSeer X (The Pennsylvania State University) (PDF)
CiteSeer X (The Pennsylvania State University) (HTML)
PubMed (HTML)