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Liposomes asPotential CarrierSystem for TargetedDelivery of PolyeneAntibiotics Suresh R. NaikSandhya DesaiPriyank Shah2013 год

Liposomes as Potential Carrier System for Targeted Delivery of Polyene Antibiotics
review

Страница публикацииПубликация в OpenAlex
Аннотация: The development of new therapeutic modalities involves the use of drug carrier, such as liposomes, which can modify pharmacokinetic and bio-distribution of drug profile. Polyene antibiotics incorporation into liposomes improves its availability at the site, bio-distribution and therapeutic index mainly through the engulfment of liposomes by circulating monocytes/macrophages and transportation to the site of infection. Polyene antibiotics (AmB, SJA-95, HA-1-92) and other antibiotics (streptomycin, tobramycin, quinolones, anti-tubercular and anti-cancer drugs), liposomal preparations are described with possible advantages from therapeutic efficacy and toxicity point of view. The polyene macrolide antibiotics liposomal preparations proved to be more effective in the treatment of systemic mycosis. The AmB-cyclodextrin derivatives inclusion complex is a major breakthrough in liposomal preparation which can be converted into aqueous phase of liposome. Liposomal drug incorporated preparation has been one of the important areas of research for developing the existing polyene antibiotics into useful chemotherapeutic agents in clinical medicine. In recent past other antibiotics have also been incorporated into liposomes using wide variety of materials, phosphatidylethanolamine derivatives (pegylated liposomes, enzyme sensitive conjugates, fluidosomes of anti-cancer drugs and poly lactic/glycolic acid microspheres for anti-tuberculosis drugs). In addition, attempts were also made to extend the receptor mediated drug targeting and to review some relevant patents. Keywords: Chemotherapeutic activity, decreased toxicity, liposomes, pharmacokinetics, polyene antibiotics.
Год издания: 2013
Авторы: Suresh R. Naik, Sandhya Desai, Priyank Shah, Santosh Wala
Издательство: Bentham Science Publishers
Источник: Recent Patents on Inflammation & Allergy Drug Discovery
Ключевые слова: Synthesis of β-Lactam Compounds, Monoclonal and Polyclonal Antibodies Research, Nanoparticle-Based Drug Delivery
Другие ссылки: Recent Patents on Inflammation & Allergy Drug Discovery (HTML)
PubMed (HTML)