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ImmunosuppressiveStrategies that areMediated by TumorCells Gabriel A. RabinovichDmitry I. GabrilovichEduardo M. Sotomayor2006 год

Immunosuppressive Strategies that are Mediated by Tumor Cells
review

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Despite major advances in understanding the mechanisms leading to tumor immunity, a number of obstacles hinder the successful translation of mechanistic insights into effective tumor immunotherapy. Such obstacles include the ability of tumors to foster a tolerant microenvironment and the activation of a plethora of immunosuppressive mechanisms, which may act in concert to counteract effective immune responses. Here we discuss different strategies employed by tumors to thwart immune responses, including tumor-induced impairment of antigen presentation, the activation of negative costimulatory signals, and the elaboration of immunosuppressive factors. In addition, we underscore the influence of regulatory cell populations that may contribute to this immunosuppressive network; these include regulatory T cells, natural killer T cells, and distinct subsets of immature and mature dendritic cells. The current wealth of preclinical information promises a future scenario in which the synchronized blockade of immunosuppressive mechanisms may be effective in combination with other conventional strategies to overcome immunological tolerance and promote tumor regression.
Год издания: 2006
Авторы: Gabriel A. Rabinovich, Dmitry I. Gabrilovich, Eduardo M. Sotomayor
Издательство: Annual Reviews
Источник: Annual Review of Immunology
Ключевые слова: Immune Cell Function and Interaction, Immunotherapy and Immune Responses, CAR-T cell therapy research
Другие ссылки: Annual Review of Immunology (HTML)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (PDF)
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Europe PMC (PubMed Central) (HTML)
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