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The transition tomenopause reinforcesadiponectinproduction and itscontribution toimprovement ofinsulin‐resistantstate Koji TamakoshiHiroshi YatsuyaKeiko Wada2006 год

The transition to menopause reinforces adiponectin production and its contribution to improvement of insulin‐resistant state
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Аннотация: Summary Objective To evaluate the influence of menopausal status on the serum adiponectin concentration and investigate whether the contribution of adiponectin to insulin resistance is modified by menopausal status. Subjects We conducted a population‐based, cross‐sectional study of 207 premenopausal and 206 postmenopausal Japanese women. Measurements Data on anthropometric characteristics, fasting serum adiponectin, glucose and insulin concentrations were used. Insulin resistance (homeostasis model assessment of insulin resistance: HOMA‐IR) was calculated. Results Postmenopausal women had significantly higher HOMA‐IRs than premenopausal women [1·50 (1·42, 1·59) vs 1·18 (1·12, 1·24), geometric mean (1 standard error range), P = 0·005]. Paradoxically, adiponectin levels in postmenopausal women were also significantly higher than those in premenopausal women [10·3 (9·95, 10·7) vs 9·04 (8·71, 9·39), P = 0·028]. Multiple regression analysis showed that body mass index (BMI) was the only significantly independent predictor [standardized partial regression coefficients (sβ) = 0·319, P < 0·001] for HOMA‐IR among premenopausal women, whereas both BMI and adiponectin were the significant predictors among postmenopausal (sβ = 0·334 and −0·141, P < 0·001 and < 0·05, respectively). When the subjects were restricted to those without metabolic disorders including high blood pressure, hypertriglyceridaemia, hypo‐HDL cholesterolaemia and high fasting glucose, adiponectin (sβ = −0·249, P < 0·05) was the only significant predictor for HOMA‐IR among postmenopausal women but BMI was not significant (sβ = 0·223, P = 0·075). Conclusions The transition to menopause increases serum adiponectin concentrations. And the significant and negative association between adiponectin and HOMA‐IR was observed only after menopause. Therefore, adiponectin may play a role in the improvement of an incipient insulin‐resistant state after, rather than before, menopause.
Год издания: 2006
Авторы: Koji Tamakoshi, Hiroshi Yatsuya, Keiko Wada, Kunihiro Matsushita, Rei Otsuka, Pei Ou Yang, Kaichiro Sugiura, Yo Hotta, Hirotsugu Mitsuhashi, Seiko Takefuji, Takaaki Kondo, Hideaki Toyoshima
Издательство: Wiley
Источник: Clinical Endocrinology
Ключевые слова: Adipokines, Inflammation, and Metabolic Diseases, Regulation of Appetite and Obesity, Adipose Tissue and Metabolism
Другие ссылки: Clinical Endocrinology (HTML)
PubMed (HTML)