Аннотация:Abstract This paper reviews our investigations on the chemical constituents of several kinds of botanically identified licorice roots, which led to the characterization of 13 then-new glucuronide-saponins named licorice-saponins (AL), apioglycyrrhizin, and araboglycyrrhizin, together with glycyrrhizin and 18α-glycyrrhizin and also of 49 kinds of phenolic compounds and their glycosides (11 then-new). The restoration-promoting activity of licorice-saponin B2 for CCl 4 -intoxicated hepatocyte function and the structuresweetness relationship of saponins were discussed. Biologically interesting, but isolable in minor quantities, several licorice-saponins were favorably synthesized from abundantly available glycyrrhizin. With 15 saponins and 49 phenolic compounds (including their glycosides) at hand, chemical evaluation of licorice root processings was undertaken. It was shown that the cortex contained a rich amount of phenolic compounds, whereas the xylem was rich in phenolic glycosides and the saponins contained were richer in the xylem than in the cortex. It was also found that roasted licorice root contained an increased amount of glycyrrhetic acid monoglucuronide, which was secondarily formed from glycyrrhizin through thermal hydrolysis and was known to taste 5 times sweeter than glycyrrhizin.
Издательство:International Union of Pure and Applied Chemistry
Источник:Pure and Applied Chemistry
Ключевые слова:Pharmacological Effects of Natural Compounds, Phytochemistry and biological activity of medicinal plants, Ginseng Biological Effects and Applications
