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Measurement andEstimation of GFR inChildren andAdolescents George J. SchwartzDana F. Work2009 год

Measurement and Estimation of GFR in Children and Adolescents
review

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Аннотация: GFR is the best indicator of renal function in children and adolescents and is critical for diagnosing acute and chronic kidney impairment, intervening early to prevent end-stage renal failure, prescribing nephrotoxic drugs and drugs cleared by a failing kidney, and monitoring for side effects of medications. Renal inulin clearance was the gold standard for GFR but is compromised by lack of availability, difficult assays, and problems of collecting timed urine samples, especially in children with vesicoureteral reflux or bladder dysfunction. Creatinine clearance-based estimates of GFR are often used in pediatrics. The addition of cimetidine to eliminate creatinine secretion permits accurate measurement of GFR in those who can completely empty their bladders to provide timed urine collections. Radioisotopes are used in plasma disappearance GFR determinations; however, these are not ideal for use in children, especially for repeated studies. The plasma disappearance of iohexol serves as a promising alternative GFR marker, because it is safe and not radioactive, easily measured, not metabolized or transported by the kidney, and excreted primarily by glomerular filtration. GFR estimating equations, based on serum concentrations of creatinine or cystatin C, are popular clinically and in research studies. Efforts are ongoing to improve these estimating equations for children and make the results readily available to clinicians obtaining standard chemistry profiles, as is being done for adults. However, at this time, there is no dependable substitute for an accurately determined GFR, and iohexol plasma disappearance offers the best combination of safety, accuracy, and reproducible precision.
Год издания: 2009
Авторы: George J. Schwartz, Dana F. Work
Издательство: Lippincott Williams & Wilkins
Источник: Clinical Journal of the American Society of Nephrology
Ключевые слова: Pediatric Urology and Nephrology Studies, Acute Kidney Injury Research, Chronic Kidney Disease and Diabetes
Другие ссылки: Clinical Journal of the American Society of Nephrology (HTML)
journals.lww.com (HTML)
PubMed (HTML)