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Functionalimplications ofcalcium permeabilityof the channel formedby pannexin 1 Fabien Vanden AbeeleGabriel BidauxDmitri Gordienko2006 год

Functional implications of calcium permeability of the channel formed by pannexin 1
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Аннотация: Although human pannexins (PanX) are homologous to gap junction molecules, their physiological function in vertebrates remains poorly understood. Our results demonstrate that overexpression of PanX1 results in the formation of Ca2+-permeable gap junction channels between adjacent cells, thus, allowing direct intercellular Ca2+ diffusion and facilitating intercellular Ca2+ wave propagation. More intriguingly, our results strongly suggest that PanX1 may also form Ca2+-permeable channels in the endoplasmic reticulum (ER). These channels contribute to the ER Ca2+ leak and thereby affect the ER Ca2+ load. Because leakage remains the most enigmatic of those processes involved in intracellular calcium homeostasis, and the molecular nature of the leak channels is as yet unknown, the results of this work provide new insight into calcium signaling mechanisms. These results imply that for vertebrates, a new protein family, referred to as pannexins, may not simply duplicate the connexin function but may also provide additional pathways for intra- and intercellular calcium signaling and homeostasis.
Год издания: 2006
Авторы: Fabien Vanden Abeele, Gabriel Bidaux, Dmitri Gordienko, Benjamin Beck, Yuri V. Panchin, Ancha Baranova, Dmitry Ivanov, Roman Skryma, Natalia Prevarskaya
Издательство: Rockefeller University Press
Источник: The Journal of Cell Biology
Ключевые слова: Connexins and lens biology, Nicotinic Acetylcholine Receptors Study, Biochemical effects in animals
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