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Hydro‐spinning: Anovel technology formakingalginate/chitosanfibrous scaffold Jianzheng WangXiaobo HuangJing Xiao2009 год

Hydro‐spinning: A novel technology for making alginate/chitosan fibrous scaffold
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Аннотация: Abstract Alginate/chitosan polyelectrolyte complex (PEC) hybrid fibers are promising materials for scaffold‐making in tissue engineering. In this study, a new method termed “hydro‐spinning” was developed to make alginate/chitosan hybrid fibers. In hydro‐spinning, a chitosan solution was pumped into a flowing sodium alginate solution and sheared into streamlines. These elongated streamlines subsequently transformed into alginate/chitosan PEC ribbon‐like fibers before breaking up into pieces. Average diameter and chitosan content of the fibers correlated positively with the chitosan concentration used in spinning. These hybrid fibers showed a high water‐absorbability of around 50‐fold to 60‐fold of water to their dry weight and could retain their integrity after saturation in minimum essential medium (MEM) medium for 30 days. In vitro culture experiments demonstrated that these fibers were able to support the three‐dimensional growth of MCF‐7, suggesting the potential applications of these fibers in biomedical and bioengineering fields such as tissue engineering. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010
Год издания: 2009
Авторы: Jianzheng Wang, Xiaobo Huang, Jing Xiao, Wei Yu, Wei Wang, Weiyang Xie, Ying Zhang, Xiaojun Ma
Издательство: Wiley
Источник: Journal of Biomedical Materials Research Part A
Ключевые слова: Electrospun Nanofibers in Biomedical Applications, Polymer Surface Interaction Studies, Silk-based biomaterials and applications
Другие ссылки: Journal of Biomedical Materials Research Part A (HTML)
PubMed (HTML)