1. Главная
  2. Ресурсы
  3. Библиотечный поиск
Desensitization ofthe cough reflex byexercise andvoluntary isocapnichyperpnea Federico LavoriniGiovanni FontanaElisa Chellini2010 год

Desensitization of the cough reflex by exercise and voluntary isocapnic hyperpnea
статья из журнала

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Little is known about the effects of exercise on the sensory and cognitive aspects of coughing evoked by inhalation of tussigenic agents. The threshold for the cough reflex induced by inhalation of increasing nebulizer outputs of ultrasonically nebulized distilled water (fog), an index of cough reflex sensitivity, was assessed in twelve healthy humans in control conditions, during exercise and during voluntary isocapnic hyperpnea (VIH) at the same ventilatory level as the exercise. The intensity of the urge to cough (UTC), a cognitive component of coughing, was recorded throughout the trials on a linear scale. The relationships between inhaled fog nebulizer outputs and the correspondingly evoked UTC values, an index of the perceptual magnitude of the UTC sensitivity, were also calculated. Cough appearance was always assessed audiovisually. At an exercise level of 80% of anaerobic threshold, the median cough threshold was increased from a control value of 0.73 to 2.22 ml/min (P<0.01), i.e., cough sensitivity was downregulated. With VIH, the threshold increased from 0.73 to 2.22 ml/min (P<0.01), a similar downregulation. With exercise and VIH compared with control, mean UTC values at cough threshold were unchanged, i.e., control, 3.83 cm; exercise, 3.12 cm; VIH, 4.08 cm. The relationship of the fog nebulizer output/UTC value was linear in control conditions and logarithmic during both exercise and VIH. The perception of the magnitude of the UTC seems to be influenced by signals or sensations arising from exercising limb and thoracic muscles and/or by higher nervous (cortical) mechanisms. The results indicate that the adjustments brought into action by exercise-induced or voluntary hyperpnea exert inhibitory influences on the sensory and cognitive components of fog-induced cough.
Год издания: 2010
Авторы: Federico Lavorini, Giovanni Fontana, Elisa Chellini, Chiara Magni, Roberto Duranti, J. G. Widdicombe
Издательство: American Physiological Society
Источник: Journal of Applied Physiology
Ключевые слова: Respiratory and Cough-Related Research, Asthma and respiratory diseases, Chronic Obstructive Pulmonary Disease (COPD) Research
Другие ссылки: Journal of Applied Physiology (HTML)
Florence Research (University of Florence) (PDF)
Florence Research (University of Florence) (HTML)
PubMed (HTML)