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Clinical,radiographic andfunctionaleffectiveness oftocilizumab forrheumatoid arthritispatients--REACTION52-week study Tsutomu TakeuchiYoshiya TanakaKoichi Amano2011 год

Clinical, radiographic and functional effectiveness of tocilizumab for rheumatoid arthritis patients--REACTION 52-week study
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Аннотация: Objectives. To evaluate the effectiveness and safety of tocilizumab in RA patients in clinical practice. Methods. We observed 232 consecutive RA patients who began tocilizumab in three rheumatology centres in Japan for 52 weeks. Clinical, radiographic and functional status and safety were evaluated. Results. Mean age of the 232 patients was 59.1 years, mean duration of disease was 12.4 years and average DAS using the 28-joint count (DAS-28) was 5.6. Although 62.8% of the patients had been treated previously with anti-TNF biologics, clinical remission at Week 52 was achieved in 43.7%, radiographic non-progression in 62.8% and functional remission in 26.4%. Retention rate at Week 52 was 71.1%, and the same for those with or without previous anti-TNF treatment. Adverse drug reactions leading to tocilizumab discontinuation were observed in 15.5% of patients, the most frequent adverse drug reaction being pneumonia in eight cases. On multivariate logistic regression analysis, DAS-28, HAQ-disability index (HAQ-DI), concomitant MTX and concomitant glucocorticoids (GCs) were predictive variables for clinical remission at Week 52 of tocilizumab treatment. In particular, HAQ-DI was found to be a predictive variable for remission of all three types—clinical, radiographic and functional—at Week 52 of tocilizumab treatment. Conclusions. In daily clinical practice, tocilizumab exhibited excellent effectiveness in established RA patients, some of whom had failed to respond to previous anti-TNF treatment. Although further detailed safety findings are required, this study provides valuable real-world findings on the management of RA with tocilizumab.
Год издания: 2011
Авторы: Tsutomu Takeuchi, Yoshiya Tanaka, Koichi Amano, Daisuke Hoshi, Masao Nawata, Hayato Nagasawa, Emília Inoue Sato, Kazuyoshi Saito, Yoko Kaneko, Shunsuke Fukuyo, Takahiko Kurasawa, Kentaro Hanami, Hideto Kameda, Hisashi Yamanaka
Издательство: Oxford University Press
Источник: Lara D. Veeken
Ключевые слова: Rheumatoid Arthritis Research and Therapies, Systemic Lupus Erythematosus Research, Autoimmune and Inflammatory Disorders Research
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