Аннотация:Abstract Mosquitoes have an efficient cellular innate immune response that includes phagocytosis of microbial pathogens and encapsulation of metozoan parasites. In this study, we describe a novel lectin in the mosquito, Armigeres subalbatus (aslectin or AL‐1). The 1.27 kb cDNA clone for the AL‐1 gene ( AL‐1 ) encodes a 279 deduced amino acid sequence that contains a C‐terminal fibrinogen‐like domain. AL‐1 is transcribed in all life stages . AL‐1 mainly exists in the haemolymph of adult female mosquitoes, and is upregulated following both Escherichia coli and Micrococcus luteus challenge. AL‐1 specifically recognizes N ‐acetyl‐ d ‐glucosamine and is able to bind both E. coli and M. luteus . These results suggest that AL‐1 might function as a pattern recognition receptor in the immune response in Ar. subalbatus .
