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Gamma InterferonRelease Assays forDetection ofMycobacteriumtuberculosisInfection Madhukar PaiClaudia M. DenkingerSandra V. Kik2014 год

Gamma Interferon Release Assays for Detection of Mycobacterium tuberculosis Infection
review

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: SUMMARY Identification and treatment of latent tuberculosis infection (LTBI) can substantially reduce the risk of developing active disease. However, there is no diagnostic gold standard for LTBI. Two tests are available for identification of LTBI: the tuberculin skin test (TST) and the gamma interferon (IFN-γ) release assay (IGRA). Evidence suggests that both TST and IGRA are acceptable but imperfect tests. They represent indirect markers of Mycobacterium tuberculosis exposure and indicate a cellular immune response to M. tuberculosis . Neither test can accurately differentiate between LTBI and active TB, distinguish reactivation from reinfection, or resolve the various stages within the spectrum of M. tuberculosis infection. Both TST and IGRA have reduced sensitivity in immunocompromised patients and have low predictive value for progression to active TB. To maximize the positive predictive value of existing tests, LTBI screening should be reserved for those who are at sufficiently high risk of progressing to disease. Such high-risk individuals may be identifiable by using multivariable risk prediction models that incorporate test results with risk factors and using serial testing to resolve underlying phenotypes. In the longer term, basic research is necessary to identify highly predictive biomarkers.
Год издания: 2014
Авторы: Madhukar Pai, Claudia M. Denkinger, Sandra V. Kik, Molebogeng X. Rangaka, Alice Zwerling, Olivia Oxlade, John Metcalfe, Adithya Cattamanchi, David W. Dowdy, Keertan Dheda, Niaz Banaei
Издательство: American Society for Microbiology
Источник: Clinical Microbiology Reviews
Ключевые слова: Tuberculosis Research and Epidemiology, Mycobacterium research and diagnosis, Infectious Diseases and Tuberculosis
Другие ссылки: Clinical Microbiology Reviews (HTML)
eScholarship (California Digital Library) (PDF)
eScholarship (California Digital Library) (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
PubMed (HTML)