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Serum Amyloid A inUremic HDL PromotesInflammation Thomas WeichhartChantal KopeckyMarkus Kubicek2012 год

Serum Amyloid A in Uremic HDL Promotes Inflammation
статья из журнала

Страница публикацииПубликация в OpenAlex
Аннотация: Uremia impairs the atheroprotective properties of HDL, but the mechanisms underlying why this occurs are unknown. Here, we observed that HDL isolated from healthy individuals inhibited the production of inflammatory cytokines by peripheral monocytes stimulated with a Toll-like receptor 2 agonist. In contrast, HDL isolated from the majority of patients with ESRD did not show this anti-inflammatory property; many HDL samples even promoted the production of inflammatory cytokines. To investigate this difference, we used shotgun proteomics to identify 49 HDL-associated proteins in a uremia-specific pattern. Proteins enriched in HDL from patients with ESRD (ESRD-HDL) included surfactant protein B (SP-B), apolipoprotein C-II, serum amyloid A (SAA), and α-1-microglobulin/bikunin precursor. In addition, we detected some ESRD-enriched proteins in earlier stages of CKD. We did not detect a difference in oxidation status between HDL isolated from uremic and healthy patients. Regarding function of these uremia-specific proteins, only SAA mimicked ESRD-HDL by promoting inflammatory cytokine production. Furthermore, SAA levels in ESRD-HDL inversely correlated with its anti-inflammatory potency. In conclusion, HDL has anti-inflammatory activities that are defective in uremic patients as a result of specific changes in its molecular composition. These data suggest a potential link between the high levels of inflammation and cardiovascular mortality in uremia.
Год издания: 2012
Авторы: Thomas Weichhart, Chantal Kopecky, Markus Kubicek, Michael Haidinger, Dominik Döller, Karl Katholnig, Cacang Suarna, Philipp Eller, Markus Tölle, Christopher Gerner, Gerhard J. Zlabinger, Markus van der Giet, Walter H. Hörl, Roland Stocker, Marcus D. Säemann
Издательство: American Society of Nephrology
Источник: Journal of the American Society of Nephrology
Ключевые слова: Dialysis and Renal Disease Management, Advanced Glycation End Products research, Chronic Kidney Disease and Diabetes
Другие ссылки: Journal of the American Society of Nephrology (HTML)
journals.lww.com (HTML)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
PubMed (HTML)