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Clonal dominanceamong T-lymphocyteinfiltrates inarthritis. Ivan StamenkovicM StegagnoK A Wright1988 год

Clonal dominance among T-lymphocyte infiltrates in arthritis.
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Аннотация: Synovial membranes in patients with rheumatoid arthritis as well as other types of chronic destructive inflammatory arthritis contain infiltrates of activated T lymphocytes that probably contribute to the pathogenesis of the disease. In an effort to elucidate the nature of these infiltrates, interleukin 2 (IL-2)-responsive T lymphocytes were grown out of synovial fragments from 14 patients undergoing surgery for advanced destructive inflammatory joint disease. Eleven of the samples examined were from patients with classical rheumatoid arthritis, while three others were obtained from individuals with clinical osteoarthritis. Southern blot analysis of T-cell receptor (TCR) beta-chain genes in 13 of 14 cultures showed distinct rearrangements, indicating that each culture was characterized by the predominance of a limited number of clones. T-cell populations from peripheral blood stimulated with a variety of activators and expanded with IL-2 did not demonstrate evidence of similar clonality in long-term culture. These results suggest that a limited number of activated T-cell clones predominate at the site of tissue injury in rheumatoid synovial membranes as well as in other types of destructive inflammatory joint disease. Further characterization of these T-cell clones may aid our understanding of the pathogenesis of these rheumatic disorders.
Год издания: 1988
Авторы: Ivan Stamenkovic, M Stegagno, K A Wright, S. M. Krane, Edward P. Amento, R B Colvin, R.J. Duquesnoy, J T Kurnick
Издательство: National Academy of Sciences
Источник: Proceedings of the National Academy of Sciences
Ключевые слова: Monoclonal and Polyclonal Antibodies Research, Systemic Lupus Erythematosus Research, T-cell and B-cell Immunology
Другие ссылки: Proceedings of the National Academy of Sciences (HTML)
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Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
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