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Effect of arterial pHand PCO2 on biliaryHCO‐3 secretion inthe pig Tom GrotmolTrond BuanesMorten G. Ræder1987 год

Effect of arterial pH and PCO2 on biliary HCO‐3 secretion in the pig
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Аннотация: The purpose of the present study was to examine the effect of changes in arterial pH and P CO 2 on biliary HCO ‐ 3 secretion. This was done in order to further characterize the various ion transport mechanisms considered responsible for biliary HC 3 secretion in the pig. Experiments were performed on two groups of six pigs. In both groups arterial pH was varied in steps from pH 7.40 to 7.40, both at P CO 2 5.5 P CO 2 and P CO 2 , 10 kPa. In group I ( n = 6), data were obtained on the effect of arterial pH and P CO 2 on ductular P CO 2 secretion in bile acid depleted (cholestyramine pretreated), secretin‐infused pigs. In group II ( n = 6), the effect of pH and P CO 2 on canalicular HCO ‐ 3 secretion was studied in ursodeoxycholic acid (UDCA)‐infused pigs (3 μml min ‐1 kg ‐1 body wt). In group I, biliary HCO ‐ 3 secretion exhibited P CO 2 ‐ dependent, positive straight line relationships to arterial pH. An increment in biliary HCO ‐ 3 secretion of 17 (11–24)% was seen during high P CO 2 at pH 7.40. In group II, biliary HCO ‐ 3 secretion exhibited P CO 2 ‐dependent, positive curvilinear relationships to arterial pH. A median increment in HCO ‐ 3 secretion of 37 (20–62)% was seen during elevated P CO 2 at arterial pH 7.40. The linear dependence of ductular HCO ‐ 3 secretion on arterial pH and the effect of elevated HCO ‐ 3 on P CO 2 secretion fit well with findings in other epithelia, where proton transport is thought be driven by a proton pump. A computer simulation provided evidence suggesting that secretin‐dependent HCO ‐ 3 secretion does not involve the action of a Na + /H + ion exchanger—in contrast to UDCA‐dependent HCO ‐ 3 secretion. It is concluded that ductular and canalicular HCO ‐ 3 secretion could be mediated by a proton pump and a Na + /H + ion exchanger in addition to canalicular HCO ‐ 3 secretion due to solvent drag and diffusion, respectively.
Год издания: 1987
Авторы: Tom Grotmol, Trond Buanes, Morten G. Ræder
Издательство: Wiley
Источник: Acta Physiologica Scandinavica
Ключевые слова: Drug Transport and Resistance Mechanisms, Neonatal Health and Biochemistry, Antibiotics Pharmacokinetics and Efficacy
Другие ссылки: Acta Physiologica Scandinavica (HTML)
PubMed (HTML)