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Mechanisms taggingsenescent red bloodcells for clearancein healthy humans Hans LutzAnna Bogdanova2013 год

Mechanisms tagging senescent red blood cells for clearance in healthy humans
review

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: This review focuses on the analysis and evaluation of the diverse senescence markers suggested to prime red blood cells (RBC) for clearance in humans. These tags develop in the course of biochemical and structural alterations accompanying RBC aging, as the decrease of activities of multiple enzymes, the gradual accumulation of oxidative damage, the loss of membrane in form of microvesicles, the redistribution of ions and alterations in cell volume, density and deformability. The actual tags represent the penultimate galactosyl residues, revealed by desialylation of glycophorins, or the aggregates of the anion exchanger (band 3 protein) to which anti-galactose antibodies bind in the first and anti-band 3 naturally occurring antibodies (NAbs) in the second case. While anti-band 3 NAbs bind to the carbohydrate-free portion of band 3 aggreates in healthy humans, induced anti-lactoferrin antibodies bind to the carbohydrate-containing portion of band 3 and along with anti-band 3 NAbs may accelerated clearance of senescent RBC in patients with anti-neutrophil cytoplasmic antibodies. Exoplasmically accessible phosphatidylserine and the alterations in the interplay between CD47 on RBC and its receptor on macrophages, signal regulatory protein alpha (SIRPalpha protein), were also reported to induce erythrocyte clearance. We discuss the relevance of each mechanism and analyze the strength of the data.
Год издания: 2013
Авторы: Hans Lutz, Anna Bogdanova
Издательство: Frontiers Media
Источник: Frontiers in Physiology
Ключевые слова: Erythrocyte Function and Pathophysiology, Neonatal Health and Biochemistry, Hemoglobinopathies and Related Disorders
Другие ссылки: Frontiers in Physiology (PDF)
Frontiers in Physiology (HTML)
DOAJ (DOAJ: Directory of Open Access Journals) (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
Zurich Open Repository and Archive (University of Zurich) (HTML)
PubMed Central (HTML)
PubMed (HTML)