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Vitamin B12 andfolate deficiency inlater life Robert ClarkeJ. Grimley EvansJ Schneede2003 год

Vitamin B12 and folate deficiency in later life
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Аннотация: Objectives: to examine the prevalence of vitamin B12 deficiency and folate deficiency in later life in representative samples of the elderly population in the United Kingdom. Design: a population-based cross-sectional analysis of 3,511 people aged 65 years or older from three studies was used to estimate the age-specific prevalence of vitamin B12 deficiency and of folate deficiency. Vitamin B12 deficiency is conventionally diagnosed if serum vitamin B12 < 150 pmol/l (‘low vitamin B12’). We defined ‘metabolically significant vitamin B12 deficiency’ as vitamin B12 < 200 pmol/l and blood total homocysteine >20 μmol/l. Folate deficiency, which usually refers to serum folate <5 nmol/l, was defined as ‘metabolically significant’ if serum folate was <7 nmol/l and homocysteine >20 μmol/l. Results: the prevalence of vitamin B12 deficiency, whether defined as low vitamin B12 or metabolically significant vitamin B12 deficiency increased with age in all three studies, from about 1 in 20 among people aged 65–74 years to 1 in 10 or even greater among people aged 75 years or greater. The prevalence of folate deficiency also increased with age, and was similar to that for vitamin B12 deficiencies, but only about 10% of people with low vitamin B12 levels also had low folate levels. Conclusion: the high prevalence of vitamin B12 and folate deficiency observed in older people indicates a particular need for vigilance for deficiency of these vitamins. Reliable detection and treatment of vitamin deficiency could reduce the risk of deficiency-related disability in old age.
Год издания: 2003
Авторы: Robert Clarke, J. Grimley Evans, J Schneede, Ebba Nexø, C J Bates, Astrid Fletcher, Ann Prentice, Carole Johnston, Per Magne Ueland, Helga Refsum, Paul Sherliker, Jacqueline Birks, Gary Whitlock, Elizabeth Breeze, John M. Scott
Издательство: Oxford University Press
Источник: Age and Ageing
Ключевые слова: Folate and B Vitamins Research, Fluoride Effects and Removal, Nutrition and Health in Aging
Другие ссылки: Age and Ageing (PDF)
Age and Ageing (HTML)
PubMed (HTML)