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Induction of uPArelease in humanperipheral bloodlymphocytes by[deamino-Cysl,d-Arg8]-vasopressin (dDAVP) Yoshitaka YamaguchiKen‐ichi YamadaToshikazu Suzuki2004 год

Induction of uPA release in human peripheral blood lymphocytes by [deamino-Cysl,d-Arg8]-vasopressin (dDAVP)
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Страница публикацииПубликация в OpenAlex
Аннотация: [deamino-Cys l ,d-Arg 8 ]-vasopressin (dDAVP), known to be an arginine vasopressin (AVP) V 2 receptor agonist, is an agent that increases fibrinolytic activity levels in plasma after its infusion into the human body. However, mechanisms underlying an increase and exact localization of the extrarenal dDAVP-responsive V 2 receptor remain unclarified. Two AVP receptors, V 1a and V 2 , and a related oxytocin (OT) receptor were found to be expressed in human lymphocytes. Furthermore, we found an increase of fibrinolytic activity in the medium of peripheral lymphocytes obtained from human volunteers less than 20 min after dDAVP infusion. The increased activity was also detected in the medium after incubating the lymphocytes in the presence of dDAVP in vitro, being highest at 20 min after the incubation. In accord with the increased fibrinolytic activity, the levels of urokinase-type plasminogen activator (uPA) in the medium were also increased. However, there was no significant difference of plasminogen activator inhibitor-1 (PAI-1), pro-uPA, and tissue-type plasminogen activator (tPA) concentrations in the medium between dDAVP treatment and control. When lymphocytes were preincubated with a V 2 receptor antagonist [Adamantaneacetyl 1 ,O-Et-d-Tyr 2 ,Val 4 ,Aminobutyryl 6 ,Arg 8,9 ]-vasopressin, the dDAVP-induced uPA increase was diminished. In contrast, preincubation with a V 1 receptor antagonist, [β-Mercapto-β,β-cyclopentamethylenepropionyl 1 ,O-Me-Tyr 2 ,Arg 8 ]-vasopressin, prior to dDAVP treatment resulted in a greater increase of the uPA concentration in the medium than with the dDAVP treatment alone. Thus it was suggested that dDAVP may induce uPA release from human lymphocytes via V 2 receptor-mediated reaction, and also via cross-talk between V 1 and V 2 receptors.
Год издания: 2004
Авторы: Yoshitaka Yamaguchi, Ken‐ichi Yamada, Toshikazu Suzuki, Yuping Wu, K Kita, Shunji Takahashi, Masaharu Ichinose, Nobuo Suzuki
Издательство: American Physiological Society
Источник: AJP Endocrinology and Metabolism
Ключевые слова: Neuroendocrine regulation and behavior, Neonatal Respiratory Health Research, Circadian rhythm and melatonin
Другие ссылки: AJP Endocrinology and Metabolism (HTML)
PubMed (HTML)