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Bioaccumulation andtrophic dilution ofhuman pharmaceuticalsacross trophicpositions of aneffluent-dependentwadeable stream Bowen Du‌Samuel P. HaddadAndreas Luek2014 год

Bioaccumulation and trophic dilution of human pharmaceuticals across trophic positions of an effluent-dependent wadeable stream
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Аннотация: Though pharmaceuticals are increasingly observed in a variety of organisms from coastal and inland aquatic systems, trophic transfer of pharmaceuticals in aquatic food webs have not been reported. In this study, bioaccumulation of select pharmaceuticals was investigated in a lower order effluent-dependent stream in central Texas, USA, using isotope dilution liquid chromatography-tandem mass spectrometry (MS). A fish plasma model, initially developed from laboratory studies, was tested to examine observed versus predicted internal dose of select pharmaceuticals. Pharmaceuticals accumulated to higher concentrations in invertebrates relative to fish; elevated concentrations of the antidepressant sertraline and its primary metabolite desmethylsertraline were observed in the Asian clam, Corbicula fluminea, and two unionid mussel species. Trophic positions were determined from stable isotopes (δ(15)N and δ(13)C) collected by isotope ratio-MS; a Bayesian mixing model was then used to estimate diet contributions towards top fish predators. Because diphenhydramine and carbamazepine were the only target compounds detected in all species examined, trophic magnification factors (TMFs) were derived to evaluate potential trophic transfer of both compounds. TMFs for diphenhydramine (0.38) and carbamazepine (1.17) indicated neither compound experienced trophic magnification, which suggests that inhalational and not dietary exposure represented the primary route of uptake by fish in this effluent-dependent stream.
Год издания: 2014
Авторы: Bowen Du‌, Samuel P. Haddad, Andreas Luek, William C. Scott, Gavin N. Saari, Lauren A. Kristofco, Kristin A. Connors, Christopher Rash, Joseph B. Rasmussen, C. Kevin Chambliss, Bryan W. Brooks
Издательство: Royal Society
Источник: Philosophical Transactions of the Royal Society B Biological Sciences
Ключевые слова: Pharmaceutical and Antibiotic Environmental Impacts, Toxic Organic Pollutants Impact, Isotope Analysis in Ecology
Другие ссылки: Philosophical Transactions of the Royal Society B Biological Sciences (PDF)
Philosophical Transactions of the Royal Society B Biological Sciences (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
PubMed (HTML)