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Phylogeneticcharacteristics ofthree new HIV-1 Nstrains andimplications for theorigin of group N Pierre RoquesDavid L. RobertsonSandrine Souquière2004 год

Phylogenetic characteristics of three new HIV-1 N strains and implications for the origin of group N
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Аннотация: Background: The three divergent HIV-1 groups M, N and O were very probably introduced into the human population by independent cross-species transmissions of SIVcpz from the chimpanzee subspecies Pan troglodytes troglodytes in central Africa. Objective: To characterize HIV-1 group N strains and to elucidate the group's epidemiology and relationship to HIV-1 strains O and M, and SIVcpz. Methods: DNA amplification, sequencing and phylogenetic analyses were performed to characterize viruses from three group N-infected individuals (YBF106, YBF115 and YBF116) together with YBF30 and YBF105 previously described. Results: Full-length genome sequence was determined for virus YBF106; gag, pol and env sequences were obtained for YBF116; pol (integrase) and env (gp41) fragments were obtained for YBF115. The gag, pol, 5′-vif and nef sequences were phylogenetically more closely related to HIV-1 M while 3′-vif, vpr, tat, vpu and env clustered with SIVcpz from P. t. troglodytes. Sequence analysis revealed no mutations potentially responsible for drug resistance. Conclusions: The finding that all group N viruses displayed the same recombinant structure and were monophyletic indicates that a single transfer event of SIVcpz to humans can account for the origin of this group. Despite the pathogenic outcome of the known group N infections, the extremely low prevalence of this divergent HIV-1 suggests that this group is not an emerging threat to human health at the present time. However, continuous monitoring of HIV-1 diversity will be important to survey the potential of unusual HIV infections, such as group N, to contribute to the HIV/AIDS pandemic.
Год издания: 2004
Авторы: Pierre Roques, David L. Robertson, Sandrine Souquière, Cristian Apetrei, Eric Nerrienet, Françoise Barré‐Sinoussi, Michaela Müller‐Trutwin, François Simon
Издательство: Lippincott Williams & Wilkins
Источник: AIDS
Ключевые слова: HIV Research and Treatment, Virology and Viral Diseases, Bacteriophages and microbial interactions
Другие ссылки: AIDS (HTML)
PubMed (HTML)