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A Prospective Studyof Mercury ToxicityBiomarkers inAutistic SpectrumDisorders∗ David A. GeierMark R. Geier2007 год

A Prospective Study of Mercury Toxicity Biomarkers in Autistic Spectrum Disorders∗
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Страница публикацииПубликация в OpenAlex
Аннотация: Abstract Porphyrins are derivatives formed in the heme synthesis pathway and porphyrins afford a measure of xenobiotic exposure. The steps in the heme pathway most vulnerable to heavy metal inhibition are uroporphyrin decarboxylase (UROD) and coproporphyrinogen oxidase (CPOX) reactions. Mercury toxicity was associated with elevations in urinary coproporphyrin (cP), pentacarboxyporphyrin (5cxP), and precoproporphyrin (prcP) (also known as keto-isocoproporphyrin) levels. Two cohorts of autistic patients in the United States and France had urine porphyrin levels associated with mercury toxicity. A prospective study of urinary porphyrin testing at LabCorp (United States) and the Laboratoire Philippe Auguste (France) involving 71 autism spectrum disorder (ASD) patients, neurotypical sibling controls, and general population controls was undertaken. ASD patients had significant elevations in urinary levels of cP, 5cxP, and prcP relative to controls, and > 50% of ASD patients had urinary cP levels more than 2 standard deviations above the mean values for neurotypical sibling controls. Significant reductions in urinary 5cxP and cP levels were observed in ASD patients following chelation. A significant correlation was found between urinary porphyrins measured at LabCorp and those measured at the Laboratoire Philippe Auguste on individual ASD patients. The established developmental neurotoxicity attributed to mercury and biochemical/genomic evidence for mercury susceptibility/toxicity in ASDs indicates a causal role for mercury. Urinary porphyrin testing is clinically available, relatively inexpensive, and noninvasive. Porphyrins need to be routinely measured in ASDs to establish if mercury toxicity is a causative factor and to evaluate the effectiveness of chelation therapy. This study was supported by the nonprofit Institute of Chronic Illnesses (Silver Spring, MD) through a grant from the Brenen Hornstein Autism Research & Education (BHARE) Foundation (Elk Grove, IL).
Год издания: 2007
Авторы: David A. Geier, Mark R. Geier
Издательство: Taylor & Francis
Источник: Journal of Toxicology and Environmental Health
Ключевые слова: Neonatal Health and Biochemistry, Heme Oxygenase-1 and Carbon Monoxide, Porphyrin Metabolism and Disorders
Другие ссылки: Journal of Toxicology and Environmental Health (HTML)
PubMed (HTML)