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Secretory productsfrom human adipocytesstimulateproinflammatorycytokine secretionfrom humanendothelial cells Grit SommerSusan KralischVerena Stangl2009 год

Secretory products from human adipocytes stimulate proinflammatory cytokine secretion from human endothelial cells
статья из журнала

Страница публикацииПубликация в OpenAlex
Аннотация: Abstract Hyperplasia and hypertrophy of fat cells can be found in obesity and increased adiposity is associated with endothelial dysfunction as an early event of atherosclerosis. However, it is unclear whether human adipocytes directly influence endothelial protein secretion. To study the crosstalk between fat and endothelial cells, human umbilical venous endothelial cells (HUVECs) were cultured in infranatants (Adipo) of primary differentiated human adipocytes. Interestingly, significantly increased secretion of 23 cytokines and chemokines from HUVECs was detected in four independent experiments after Adipo stimulation by protein array analysis detecting a total of 174 different proteins. Among those, time‐dependent Adipo‐induced upregulation of cytokine secretion in HUVECs was confirmed by ELISA for interleukin (IL)‐8, monokine induced by gamma interferon, macrophage inflammatory protein (MIP)‐1β, MIP‐3α, monocyte chemoattractant protein‐1, and IL‐6. Factors besides adiponectin, leptin, resistin, and tumor necrosis factor α appear to mediate these stimulatory effects. Our findings suggest that endothelial cell secretion is significantly influenced towards a proinflammatory pattern by adipocyte‐secreted factors. J. Cell. Biochem. 106: 729–737, 2009. © 2009 Wiley‐Liss, Inc.
Год издания: 2009
Авторы: Grit Sommer, Susan Kralisch, Verena Stangl, Angelika Vietzke, Uwe Köhler, Holger Stepan, R Faber, Andreas Schubert, Ulrike Lössner, Matthias Blüher, Michael Stümvoll, Mathias Faßhauer
Издательство: Wiley
Источник: Journal of Cellular Biochemistry
Ключевые слова: Adipokines, Inflammation, and Metabolic Diseases, Adipose Tissue and Metabolism, Atherosclerosis and Cardiovascular Diseases
Другие ссылки: Journal of Cellular Biochemistry (HTML)
PubMed (HTML)