Аннотация:Endoscopic mucosal resection (EMR) was applied in an 80‐year‐old Japanese man with stage I hypopharyngeal cancer because he refused further radical therapy after esophagogastrectomy for gastric and esophageal cancers. Although EMR was successfully performed without complications, histopathologic investigation revealed cancer‐positive lateral margins. Furthermore, another biopsy from the right aryepiglottic fold yielded a diagnosis of laryngeal cancer. Radiation therapy was ultimately performed because of the possibility of residual tumor and coexistent laryngeal cancer. Endoscopic mucosal resection as a curative treatment for hypopharyngeal cancer is associated with several problems that must be resolved before general application is feasible. However, the present case, at least, shows the possibility of using EMR as a diagnostic procedure and as a less invasive palliative treatment.