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Glucose regulation incaptivePongo pygmaeusabeli, P. p.pygmaeus,andP. p.abeli x P. p.pygmaeusorangutans Theresa A. GreslScott T. BaumJoseph W. Kemnitz2000 год

Glucose regulation in captivePongo pygmaeus abeli, P. p. pygmaeus,andP. p. abeli x P. p. pygmaeusorangutans
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Аннотация: Intravenous glucose tolerance tests (IVGTT) were performed on 30 anesthetized, captive Sumatran (Pongo pygmaeus abeli), Bornean (P. p. pygmaeus), and hybrid (P. p. ablie x P. p. pygmaeus) orangutans, and fasted blood samples were taken from two additional juvenile orangutans in 11 U.S. zoos from 1989 to 1997. The age range of animals was 3.5 to 40.5 years. Plasma and serum samples were assayed for glucose and insulin concentrations. Glucose disappearance rate (KG), an index of glucose tolerance, was calculated, as were the early (acute) and second phase insulin responses to administered glucose. The mean ± SE (and median) fasting glucose and insulin concentrations were 113 ± 16 mg/dL (90 mg/dL) and 45 ± 7 μU/mL (27 μU/mL), respectively. Two animals previously suspected to be diabetic were easily identified by their markedly elevated fasting glucose concentrations (380 and 562 mg/dL) and relatively low fasted insulin concentrations (21 and 14 μU/mL); their insulin responses during the IVGTTs were also low or non-detectable. Without these diabetics, the mean ± SE (median) fasting glucose concentration was 92 ± 18 mg/dL (89 mg/dL). Two animals, ages 18 and 40, were identified as potentially pre-diabetic based on age, adiposity, elevated fasted glucose (116 and 137 mg/dL, respectively), and elevated fasted insulin concentrations (114 and 217 μU/mL, respectively). In addition, nearly half of the animals of varying ages, all sub-species and both sexes exhibited delayed or attenuated acute insulin responses during the IVGTTs, resulting in lower KG (P < 0.04) and suggesting propensity for glucose intolerance in captive orangutans. Glucose and insulin concentrations and insulin responses to glucose did not differ between females on hormonal contraception regimes and those not receiving treatment. Zoo Biol 19:193–208, 2000. © 2000 Wiley-Liss, Inc.
Год издания: 2000
Авторы: Theresa A. Gresl, Scott T. Baum, Joseph W. Kemnitz
Издательство: Wiley
Источник: Zoo Biology
Ключевые слова: Adipokines, Inflammation, and Metabolic Diseases, Peroxisome Proliferator-Activated Receptors, Adipose Tissue and Metabolism