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Inflammatory markersand extent andprogression of earlyatherosclerosis:Meta-analysis ofindividual-participant-data from 20prospective studiesof the… Peter WilleitSimon G. ThompsonStefan Agewall2014 год

Inflammatory markers and extent and progression of early atherosclerosis: Meta-analysis of individual-participant-data from 20 prospective studies of the PROG-IMT collaboration
review

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Аннотация: Large-scale epidemiological evidence on the role of inflammation in early atherosclerosis, assessed by carotid ultrasound, is lacking. We aimed to quantify cross-sectional and longitudinal associations of inflammatory markers with common-carotid-artery intima-media thickness (CCA-IMT) in the general population. Information on high-sensitivity C-reactive protein, fibrinogen, leucocyte count and CCA-IMT was available in 20 prospective cohort studies of the PROG-IMT collaboration involving 49,097 participants free of pre-existing cardiovascular disease. Estimates of associations were calculated within each study and then combined using random-effects meta-analyses. Mean baseline CCA-IMT amounted to 0.74 mm (SD = 0.18) and mean CCA-IMT progression over a mean of 3.9 years to 0.011 mm/year (SD = 0.039). Cross-sectional analyses showed positive linear associations between inflammatory markers and baseline CCA-IMT. After adjustment for traditional cardiovascular risk factors, mean differences in baseline CCA-IMT per one-SD higher inflammatory marker were: 0.0082 mm for high-sensitivity C-reactive protein (p < 0.001); 0.0072 mm for fibrinogen (p < 0.001); and 0.0025 mm for leucocyte count (p = 0.033). 'Inflammatory load', defined as the number of elevated inflammatory markers (i.e. in upper two quintiles), showed a positive linear association with baseline CCA-IMT (p < 0.001). Longitudinal associations of baseline inflammatory markers and changes therein with CCA-IMT progression were null or at most weak. Participants with the highest 'inflammatory load' had a greater CCA-IMT progression (p = 0.015). Inflammation was independently associated with CCA-IMT cross-sectionally. The lack of clear associations with CCA-IMT progression may be explained by imprecision in its assessment within a limited time period. Our findings for 'inflammatory load' suggest important combined effects of the three inflammatory markers on early atherosclerosis.
Год издания: 2014
Авторы: Peter Willeit, Simon G. Thompson, Stefan Agewall, Göran Bergström, Horst Bickel, Alberico L. Catapano, Kuo‐Liong Chien, Eric de Groot, Jean–Philippe Empana, Thorleif Etgen, Oscar H. Franco, Bernhard Iglseder, Stein Harald Johnsen, Maryam Kavousi, Lars Lind, Jing Liu, Ellisiv B. Mathiesen, Giuseppe Danilo Norata, Michael Hecht Olsen, Αikaterini Papagianni, Holger Poppert, Jackie F. Price, Ralph L. Sacco, David N. Yanez, Dong Zhao, Ulf Schminke, Alpaslan Bülbül, Joseph F. Polak, Matthias Sitzer, Albert Hofman, Liliana Grigore, Marcus Dörr, Ta‐Chen Su, Pierre Ducimetière, Wuxiang Xie, Kimmo Ronkainen, Stefan Kiechl, Tatjana Rundek, C. Robertson, Björn Fagerberg, Lena Bokemark, Helmuth Steinmetz, M. Arfan Ikram, Henry Völzke, Hung‐Ju Lin, Matthieu Plichart, Tomi-Pekka Tuomainen, Moı̈se Desvarieux, Stela McLachlan, Caroline Schmidt, Jussi Kauhanen, Johann Willeit, Matthias Lorenz, Dirk Sander
Издательство: Oxford University Press
Источник: European Journal of Preventive Cardiology
Ключевые слова: Adipokines, Inflammation, and Metabolic Diseases, Cardiovascular Health and Disease Prevention, Atherosclerosis and Cardiovascular Diseases
Другие ссылки: European Journal of Preventive Cardiology (PDF)
European Journal of Preventive Cardiology (HTML)
University of Southern Denmark Research Portal (University of Southern Denmark) (PDF)
University of Southern Denmark Research Portal (University of Southern Denmark) (HTML)
PubMed Central (HTML)
University of Southern Denmark Research Portal (University of Southern Denmark) (PDF)
University of Southern Denmark Research Portal (University of Southern Denmark) (HTML)
PubMed (HTML)