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Spontaneous bacterialperitonitis: recentguidelines and beyond Roland WiestAleksander KragA. Gerbes2011 год

Spontaneous bacterial peritonitis: recent guidelines and beyond
review

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Аннотация:

Background

Patients with primary intracerebral haemorrhage (ICH) are at increased long-term risks of recurrent stroke and other comorbidities. However, available estimates come predominantly from hospital-based studies with relatively short follow-up. Moreover, there are also uncertainties about the influence of ICH location on risks of recurrent stroke, disability, dementia and quality of life.

Methods

In a population-based study (Oxford Vascular Study/2002–2018) of patients with a first ICH with follow-up to 10 years, we determined the long-term risks of recurrent stroke, disability, quality of life, dementia and hospital care costs stratified by haematoma location.

Results

Of 255 cases with primary ICH (mean/SD age 75.5/13.1), 109 (42.7%) had lobar ICH, 144 (56.5%) non-lobar ICH and 2 (0.8%) had uncertain location. Annual rates of recurrent ICH were higher after lobar versus non-lobar ICH (lobar=4.0%, 2.7–7.2 vs 1.1%, 0.3–2.8; p=0.02). Moreover, cumulative rate of dementia was also higher for lobar versus non-lobar ICH (n/% lobar=20/36.4% vs 16/20.8%, p=0.047), and there was a higher proportion of disability at 5 years in survivors (15/60.0% vs 9/31.0%, p=0.03). The 10-year quality-adjusted life years (QALYs) were also lower after lobar versus non-lobar ICH (2.9 vs 3.8 for non-lobar, p=0.04). Overall, the mean 10-year censor-adjusted costs were £19 292, with over 80% of costs due to inpatient hospital admission costs, which did not vary by haematoma location (p=0.90).

Conclusion

Compared with non-lobar ICH, the substantially higher 10-year risks of recurrent stroke, dementia and lower QALYs after lobar ICH highlight the need for more effective prevention for this patient group.
Год издания: 2011
Авторы: Roland Wiest, Aleksander Krag, A. Gerbes
Издательство: BMJ
Источник: Gut
Ключевые слова: Liver Disease and Transplantation, Intracerebral and Subarachnoid Hemorrhage Research, Dialysis and Renal Disease Management
Другие ссылки: Gut (HTML)
CiteSeer X (The Pennsylvania State University) (PDF)
CiteSeer X (The Pennsylvania State University) (HTML)
Open access LMU (Ludwid Maxmilian's Universitat Munchen) (PDF)
Open access LMU (Ludwid Maxmilian's Universitat Munchen) (HTML)
PubMed (HTML)