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Tissue-specificexpression andregulation ofsexually dimorphicgenes in mice Xia YangEric E. SchadtSusanna Wang2006 год

Tissue-specific expression and regulation of sexually dimorphic genes in mice
статья из журнала

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Аннотация: We report a comprehensive analysis of gene expression differences between sexes in multiple somatic tissues of 334 mice derived from an intercross between inbred mouse strains C57BL/6J and C3H/HeJ. The analysis of a large number of individuals provided the power to detect relatively small differences in expression between sexes, and the use of an intercross allowed analysis of the genetic control of sexually dimorphic gene expression. Microarray analysis of 23,574 transcripts revealed that the extent of sexual dimorphism in gene expression was much greater than previously recognized. Thus, thousands of genes showed sexual dimorphism in liver, adipose, and muscle, and hundreds of genes were sexually dimorphic in brain. These genes exhibited highly tissue-specific patterns of expression and were enriched for distinct pathways represented in the Gene Ontology database. They also showed evidence of chromosomal enrichment, not only on the sex chromosomes, but also on several autosomes. Genetic analyses provided evidence of the global regulation of subsets of the sexually dimorphic genes, as the transcript levels of a large number of these genes were controlled by several expression quantitative trait loci (eQTL) hotspots that exhibited tissue-specific control. Moreover, many tissue-specific transcription factor binding sites were found to be enriched in the sexually dimorphic genes.
Год издания: 2006
Авторы: Xia Yang, Eric E. Schadt, Susanna Wang, Hui Wang, Arthur P. Arnold, Leslie Ingram-Drake, Thomas A. Drake, Aldons J. Lusis
Издательство: Cold Spring Harbor Laboratory Press
Источник: Genome Research
Ключевые слова: Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities, Sex and Gender in Healthcare, Genetic Mapping and Diversity in Plants and Animals
Другие ссылки: Genome Research (PDF)
Genome Research (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
PubMed (HTML)