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SelectiveVulnerability of LateOligodendrocyteProgenitors toHypoxia–Ischemia Stephen A. BackByung Hee HanNing Luo2002 год

Selective Vulnerability of Late Oligodendrocyte Progenitors to Hypoxia–Ischemia
статья из журнала

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: In the premature infant, hypoxic-ischemic damage to the cerebral white matter [periventricular leukomalacia (PVL)] is a common and leading cause of brain injury that often results in chronic neurologic disability from cerebral palsy. The cellular basis for the propensity of white matter injury to occur in the developing brain and the greater resistance of the adult white matter to similar injury remains unknown. By using a neonatal rat model of hypoxic-ischemic injury, we found that the mechanism of perinatal white matter injury involved maturation-dependent vulnerability in the oligodendroctye (OL) lineage. The timing of appearance of late OL progenitors was the major developmental factor that accounted for the susceptibility of the neonatal white matter to injury. Late OL progenitors were the major OL lineage stage killed by apoptosis, whereas early OL progenitors and more mature OLs were highly resistant. The density of pyknotic late OL progenitors was significantly increased in the ischemic hemisphere (67 ± 31 cells/mm2) versus the control hemisphere (2.2 ± 0.4 cells/mm2; mean ± SEM; p = 0.05), which resulted in the death of 72 ± 6% of this OL stage. Surviving late OL progenitors displayed a reactive response in which an increase in cell density was accompanied by accelerated maturation to a P27/kip1-positive oligodendrocyte. Because we showed recently that late OL progenitors populate human cerebral white matter during the high risk period for PVL (Back et al., 2001), maturation-dependent vulnerability of OL progenitors to hypoxia–ischemia may underlie the selective vulnerability to PVL of the white matter in the premature infant.
Год издания: 2002
Авторы: Stephen A. Back, Byung Hee Han, Ning Luo, Charlene A. Chricton, Steve Xanthoudakis, John Tam, Kara L. Arvin, David M. Holtzman
Издательство: Society for Neuroscience
Источник: Journal of Neuroscience
Ключевые слова: Neonatal and fetal brain pathology, Neonatal Respiratory Health Research, Hyperglycemia and glycemic control in critically ill and hospitalized patients
Другие ссылки: Journal of Neuroscience (PDF)
Journal of Neuroscience (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
PubMed (HTML)