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Prognosticsignificance ofapoptosis regulatorsin breast cancer. Stanisław KrajewskiMaryla KrajewskaBruce Turner1999 год

Prognostic significance of apoptosis regulators in breast cancer.
review

Страница публикацииПубликация в OpenAlex
Аннотация: Dysregulation of normal programmed cell death mechanisms plays an important role in the pathogenesis and progression of breast cancer, as well as in responses of tumors to therapeutic intervention. Overexpression of anti-apoptotic members of the Bcl-2 family such as Bcl-2 and Bcl-X(L) has been implicated in cancer chemoresistance, whereas high levels of pro-apoptotic proteins such as Bax promote apoptosis and sensitize tumor cells to various anticancer therapies. Though the mechanisms by which Bcl-2 family proteins regulate apoptosis are diverse, ultimately they govern decision steps that determine whether certain caspase family cell death proteases remain quiescent or become active. To date, approximately 17 cellular homologs of Bcl-2 and at least 15 caspases have been identified in mammals. Other types of proteins may also modulate apoptotic responses through effects on apoptosis-regulatory proteins, such as BAG-1-a heat shock protein 70 kDa (Hsp70/Hsc70)-binding protein that can modulate stress responses and alter the functions of a variety of proteins involved in cell death and division. In this report, we summarize our attempts thus far to explore the expression of several Bcl-2 family proteins, caspase-3, and BAG-1 in primary breast cancer specimens and breast cancer cell lines. Moreover, we describe some of our preliminary observations concerning the prognostic significance of these apoptosis regulatory proteins in breast cancer patients, contrasting results derived from women with localized disease (with or without node involvement) and metastatic cancer.
Год издания: 1999
Авторы: Stanisław Krajewski, Maryla Krajewska, Bruce Turner, C B Pratt, Beatrice A. Howard, Juan M. Zapata, Valérie Molinier‐Frenkel, Susan J. Robertson, Yurij Ionov, Hiroshi Yamamoto, Manuel Perucho, Shinichi Takayama, John C. Reed
Издательство: Bioscientifica
Источник: Endocrine Related Cancer
Ключевые слова: Cell death mechanisms and regulation, Heat shock proteins research, Mitochondrial Function and Pathology
Другие ссылки: Endocrine Related Cancer (HTML)
PubMed (HTML)