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EGFR MutationHeterogeneity and theMixed Response toEGFR Tyrosine KinaseInhibitors of LungAdenocarcinomas Zhiyong ChenWen‐Zhao ZhongXu‐Chao Zhang2012 год

EGFR Mutation Heterogeneity and the Mixed Response to EGFR Tyrosine Kinase Inhibitors of Lung Adenocarcinomas
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Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Non-small cell lung cancer patients with epidermal growth factor receptor (EGFR) mutations have mixed responses to tyrosine kinase inhibitors (TKIs). Intertumor heterogeneity in EGFR mutations is one potential explanation for this phenomenon.We performed direct sequencing to identify EGFR mutations in 180 pairs of lung adenocarcinoma samples (from 3,071 patients). The high-resolution melting method was used in discordant cases to confirm EGFR mutation status. Matching samples were divided into four groups: primary lesions detected at different times, primary tumors with matched metastatic lymph nodes, multiple pulmonary nodules, and primary tumors with matched distant metastases. Multivariate analyses were performed to evaluate correlations between heterogeneity and patient characteristics.In the study population, the discordance rate was 13.9% (25 of 180). The multiple pulmonary nodules group had the highest discordance rate of 24.4% (10 of 41; odds ratio for heterogeneity in primary lesions detected at different times, 6.37; 95% confidence interval, 1.71-23.72; p = .006). Discordance rates in the metachronous and synchronous settings were 15.7% (22 of 140) and 7.5% (three of 40), respectively. In the 34 patients who developed EGFR TKI resistance, 10 (29.4%) cases exhibited heterogeneity and five (14.7%) patients exhibited a mixed response to the drug. Three (8.8%) of the patients with a mixed response also exhibited discordant EGFR mutations.The overall discordance rate of EGFR mutation heterogeneity in Asian patients with pulmonary adenocarcinoma is relatively low, but the rate in patients with multiple pulmonary nodules is significantly higher. This observation may explain the mixed tumor response to EGFR TKIs.
Год издания: 2012
Авторы: Zhiyong Chen, Wen‐Zhao Zhong, Xu‐Chao Zhang, Jian Su, Xue-Ning Yang, Zhi Hong Chen, Jin-Ji Yang, Qing Zhou, Hong-Hong Yan, She-Juan An, Hua-Jun Chen, Ben‐Yuan Jiang, Tony Mok, Yi‐Long Wu
Издательство: AlphaMed Press
Источник: The Oncologist
Ключевые слова: Lung Cancer Treatments and Mutations, Cancer Genomics and Diagnostics, Colorectal Cancer Treatments and Studies
Другие ссылки: The Oncologist (PDF)
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Europe PMC (PubMed Central) (PDF)
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