Аннотация:A ntibodies recognize pathogens via sequence-specific binding to Ags (1, 2).Ab-based vaccines have been extensively explored for therapeutic applications (1, 3, 4).Molecular level information about Ab-Ag recognition is important for studying immune responses and discovering vaccines and diagnostic tools.There is a scarcity of public sources for obtaining such information, and efforts are being directed at developing such resources (5, 6).We are pleased to introduce the Antibody Antigen Information Resource (AAIR) database (http://bidd.nus.edu.sg/group/antibody/antibody.asp),free of charge for academic use, to provide the relevant information reported in the literatures.It includes sequences and functions of Abs and Ags, source organism and strains, targeted diseases and therapeutic implications, Ab identification and production methods, and references.Entries are searchable by Ag name and source organism, Ab information (isotype, source organism, biochemical, and structural type), disease class and name, and therapeutic applications.A full list of these search items is provided on the Web page for facilitating a search.Disease classes are defined by the international classification of diseases of the World Health Organization (7).AAIR currently contains 2546 Ab-Ag pairs covering 177 disease conditions and 614 distinct Ag sequences from various viruses, bacteria, tumor types, and autoimmune responses.Efforts are being made to collect more data.The advances in technology for identifying Ab-Ag recognitions (8) will enable the generation of more comprehensive spectrum of data that can be incorporated into the AAIR database.
