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Minimal modelestimation of glucoseabsorption andinsulin sensitivityfrom oral test:validation with atracer method Chiara Dalla ManAndrea CaumoRita Basu2004 год

Minimal model estimation of glucose absorption and insulin sensitivity from oral test: validation with a tracer method
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Аннотация: Measuring insulin sensitivity during the physiological milieu of oral glucose perturbation, e.g., a meal or an oral glucose tolerance test, would be extremely valuable but difficult since the rate of appearance of absorbed glucose is unknown. The reference method is a tracer two-step one: first, the rate of appearance of glucose (R(a meal)(ref)) is reconstructed by employing the tracer-to-tracee ratio clamp technique with two tracers and a model of non-steady-state glucose kinetics; next, this R(a meal)(ref) is used as the known input of a model describing insulin action on glucose kinetics to estimate insulin sensitivity (SI(ref)). Recently, a nontracer method based on the oral minimal model (OMM) has been proposed to estimate simultaneously the above quantities, denoted R(a meal) and SI, respectively, from plasma glucose and insulin concentrations measured after an oral glucose perturbation. This last method has obvious advantages over the tracer method, but its domain of validity has never been assessed against a reference method. It is thus important to establish whether or not the "nontracer" R(a meal) and SI compare well with the "tracer" R(a meal)(ref) and SI(ref). We do this comparison on a database of 88 subjects, and it is very satisfactory: R(a meal) profiles agree well with the R(a meal)(ref) and correlation of SI(ref) with SI is r = 0.86 (P < 0.0001). We conclude that OMM candidates as a reliable tool to measure both the rate of glucose absorption and insulin sensitivity from oral glucose tests without employing tracers.
Год издания: 2004
Авторы: Chiara Dalla Man, Andrea Caumo, Rita Basu, Robert A. Rizza, Gianna Toffolo, Claudio Cobelli
Издательство: American Physiological Society
Источник: AJP Endocrinology and Metabolism
Ключевые слова: Diabetes Management and Research, Metabolism, Diabetes, and Cancer, Cardiovascular Function and Risk Factors
Другие ссылки: AJP Endocrinology and Metabolism (HTML)
Research Padua Archive (University of Padua) (PDF)
Research Padua Archive (University of Padua) (HTML)
Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (PDF)
Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (HTML)
PubMed (HTML)