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Proteomics ingram‐negativebacterial outermembrane vesicles Eun Young LeeDongsic ChoiKwang Pyo Kim2008 год

Proteomics in gram‐negative bacterial outer membrane vesicles
review

Страница публикацииПубликация в OpenAlex
Аннотация: Abstract Gram‐negative bacteria constitutively secrete outer membrane vesicles (OMVs) into the extracellular milieu. Recent research in this area has revealed that OMVs may act as intercellular communicasomes in polyspecies communities by enhancing bacterial survival and pathogenesis in hosts. However, the mechanisms of vesicle formation and the pathophysiological roles of OMVs have not been clearly defined. While it is obvious that mass spectrometry‐based proteomics offers great opportunities for improving our knowledge of bacterial OMVs, limited proteomic data are available for OMVs. The present review aims to give an overview of the previous biochemical, biological, and proteomic studies in the emerging field of bacterial OMVs, and to give future directions for high‐throughput and comparative proteomic studies of OMVs that originate from diverse Gram‐negative bacteria under various environmental conditions. This article will hopefully stimulate further efforts to construct a comprehensive proteome database of bacterial OMVs that will help us not only to elucidate the biogenesis and functions of OMVs but also to develop diagnostic tools, vaccines, and antibiotics effective against pathogenic bacteria. © 2008 Wiley Periodicals, Inc., Mass Spec Rev 27: 535–555, 2008
Год издания: 2008
Авторы: Eun Young Lee, Dongsic Choi, Kwang Pyo Kim, Yong Song Gho
Издательство: Wiley
Источник: Mass Spectrometry Reviews
Ключевые слова: Bacterial Infections and Vaccines, Pneumonia and Respiratory Infections, Neonatal and Maternal Infections
Другие ссылки: Mass Spectrometry Reviews (HTML)
PubMed (HTML)