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Occupation andoccupational exposureto endocrinedisrupting chemicalsin male breastcancer: acase–control study inEurope Sara VilleneuveDiane CyrElsebeth Lynge2010 год

Occupation and occupational exposure to endocrine disrupting chemicals in male breast cancer: a case–control study in Europe
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Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Male breast cancer is a rare disease of largely unknown aetiology. In addition to genetic and hormone-related risk factors, a large number of environmental chemicals are suspected of playing a role in breast cancer. The identification of occupations or occupational exposures associated with an increased incidence of breast cancer in men may help to identify mammary carcinogens in the environment.Occupational risk factors for male breast cancer were investigated in a multi-centre case-control study conducted in eight European countries which included 104 cases and 1901 controls. Lifetime work history was obtained during in-person interviews. Occupational exposures to endocrine disrupting chemicals (alkylphenolic compounds, phthalates, polychlorinated biphenyls and dioxins) were assessed on a case-by-case basis using expert judgement.Male breast cancer incidence was particularly increased in motor vehicle mechanics (OR 2.1, 95% CI 1.0 to 4.4) with a dose-effect relationship with duration of employment. It was also increased in paper makers and painters, forestry and logging workers, health and social workers, and furniture manufacture workers. The OR for exposure to alkylphenolic compounds above the median was 3.8 (95% CI 1.5 to 9.5). This association persisted after adjustment for occupational exposures to other environmental oestrogens.These findings suggest that some environmental chemicals are possible mammary carcinogens. Petrol, organic petroleum solvents or polycyclic aromatic hydrocarbons are suspect because of the consistent elevated risk of male breast cancer observed in motor vehicle mechanics. Endocrine disruptors such as alkylphenolic compounds may play a role in breast cancer.
Год издания: 2010
Авторы: Sara Villeneuve, Diane Cyr, Elsebeth Lynge, Laurent Orsi, Svend‎ Sabroe, F. Merletti, Giuseppe Gorini, María Morales‐Suárez‐Varela, Wolfgang Ahrens, Cornelia Baumgardt‐Elms, Linda Kærlev, Mikael Eriksson, Lennart Hardell, Joëlle Févotte, Pascal Guénel
Издательство: BMJ
Источник: Occupational and Environmental Medicine
Ключевые слова: Carcinogens and Genotoxicity Assessment, Effects and risks of endocrine disrupting chemicals, Male Breast Health Studies
Другие ссылки: Occupational and Environmental Medicine (HTML)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
inserm.hal.science (PDF)
inserm.hal.science (HTML)
HAL (Le Centre pour la Communication Scientifique Directe) (HTML)
HAL (Le Centre pour la Communication Scientifique Directe) (HTML)
HAL (Le Centre pour la Communication Scientifique Directe) (HTML)
HAL (Le Centre pour la Communication Scientifique Directe) (HTML)
PubMed (HTML)