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Antileishmanial andtrypanocidal activityof Brazilian Cerradoplants Mariana Laundry de MesquitaJulie DesrivotBories2005 год

Antileishmanial and trypanocidal activity of Brazilian Cerrado plants
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Аннотация: The side effects and the emerging resistance to the available drugs against leishmaniasis and trypanosomiasis led to the urgent need for new therapeutic agents against these diseases. Thirty one extracts of thirteen medicinal plants from the Brazilian Cerrado were therefore evaluated in vitro for their antiprotozoal activity against promastigotes of Leishmania donovani, and amastigotes of Trypanosoma cruzi. Among the selected plants, Casearia sylvestris var. lingua was the most active against both L. donovani and T. cruzi. Fifteen extracts were active against promastigotes of L. donovani with concentrations inhibiting 50% of parasite growth (IC50) between 0.1-10 microg/ml, particularly those of Annona crassiflora (Annonaceae), Himatanthus obovatus (Apocynaceae), Guarea kunthiana (Meliaceae), Cupania vernalis (Sapindaceae), and Serjania lethalis (Sapindaceae). With regard to amastigotes of T. cruzi, extracts of A. crassiflora, Duguetia furfuracea (Annonaceae), and C. sylvestris var. lingua were active with IC50 values between 0.3-10 microg/ml. Bioassay fractionations of the more active extracts are under progress to identify the active antiparasite compounds.
Год издания: 2005
Авторы: Mariana Laundry de Mesquita, Julie Desrivot, Bories, Alain Fournet, José Elias de Paula, Philippe Grellier, Laila Salmen Espíndola
Издательство: Instituto Oswaldo Cruz, Ministério da Saúde
Источник: Memórias do Instituto Oswaldo Cruz
Ключевые слова: Traditional and Medicinal Uses of Annonaceae, Phytochemical compounds biological activities, Carbohydrate Chemistry and Synthesis
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