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A Step-up Approach orOpen Necrosectomy forNecrotizingPancreatitis Hjalmar C. van SantvoortMarc G. BesselinkOlaf J. Bakker2010 год

A Step-up Approach or Open Necrosectomy for Necrotizing Pancreatitis
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Аннотация: Necrotizing pancreatitis with infected necrotic tissue is associated with a high rate of complications and death. Standard treatment is open necrosectomy. The outcome may be improved by a minimally invasive step-up approach.In this multicenter study, we randomly assigned 88 patients with necrotizing pancreatitis and suspected or confirmed infected necrotic tissue to undergo primary open necrosectomy or a step-up approach to treatment. The step-up approach consisted of percutaneous drainage followed, if necessary, by minimally invasive retroperitoneal necrosectomy. The primary end point was a composite of major complications (new-onset multiple-organ failure or multiple systemic complications, perforation of a visceral organ or enterocutaneous fistula, or bleeding) or death.The primary end point occurred in 31 of 45 patients (69%) assigned to open necrosectomy and in 17 of 43 patients (40%) assigned to the step-up approach (risk ratio with the step-up approach, 0.57; 95% confidence interval, 0.38 to 0.87; P=0.006). Of the patients assigned to the step-up approach, 35% were treated with percutaneous drainage only. New-onset multiple-organ failure occurred less often in patients assigned to the step-up approach than in those assigned to open necrosectomy (12% vs. 40%, P=0.002). The rate of death did not differ significantly between groups (19% vs. 16%, P=0.70). Patients assigned to the step-up approach had a lower rate of incisional hernias (7% vs. 24%, P=0.03) and new-onset diabetes (16% vs. 38%, P=0.02).A minimally invasive step-up approach, as compared with open necrosectomy, reduced the rate of the composite end point of major complications or death among patients with necrotizing pancreatitis and infected necrotic tissue. (Current Controlled Trials number, ISRCTN13975868.)
Год издания: 2010
Авторы: Hjalmar C. van Santvoort, Marc G. Besselink, Olaf J. Bakker, H. Sijbrand Hofker, Marja A. Boermeester, Cornelis H.C. Dejong, Harry van Goor, Alexander F. Schaapherder, Casper H.J. van Eijck, Thomas L. Bollen, Bert van Ramshorst, Vincent B. Nieuwenhuijs, Robin Timmer, Johan S. Laméris, Philip M. Kruyt, Eric R. Manusama, Erwin van der Harst, George P. van der Schelling, Tom M. Karsten, E. J. Hesselink, Cornelis JHM van Laarhoven, Camiel Rosman, K. Bosscha, Ralph J. de Wit, Alexander P. J. Houdijk, Maarten S. van Leeuwen, Erik Buskens, Hein G. Gooszen
Издательство: Massachusetts Medical Society
Источник: New England Journal of Medicine
Ключевые слова: Pancreatitis Pathology and Treatment, Gastrointestinal disorders and treatments, Pancreatic and Hepatic Oncology Research
Другие ссылки: New England Journal of Medicine (PDF)
New England Journal of Medicine (HTML)
University of Groningen research database (University of Groningen / Centre for Information Technology) (HTML)
Radboud Repository (Radboud University) (PDF)
Radboud Repository (Radboud University) (HTML)
Radboud Repository (Radboud University) (HTML)
PubMed (HTML)