1. Главная
  2. Ресурсы
  3. Библиотечный поиск
Dendrite architectureorganized bytranscriptionalcontrol of theF-actin nucleatorSpire Tiago FerreiraYimiao OuSally Li2014 год

Dendrite architecture organized by transcriptional control of the F-actin nucleator Spire
статья из журнала

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: The architectures of dendritic trees are crucial for the wiring and function of neuronal circuits because they determine coverage of receptive territories, as well as the nature and strength of sensory or synaptic inputs. Here, we describe a cell-intrinsic pathway sculpting dendritic arborization (da) neurons in Drosophila that requires Longitudinals Lacking (Lola), a BTB/POZ transcription factor, and its control of the F-actin cytoskeleton through Spire (Spir), an actin nucleation protein. Loss of Lola from da neurons reduced the overall length of dendritic arbors, increased the expression of Spir, and produced inappropriate F-actin-rich dendrites at positions too near the cell soma. Selective removal of Lola from only class IV da neurons decreased the evasive responses of larvae to nociception. The increased Spir expression contributed to the abnormal F-actin-rich dendrites and the decreased nocifensive responses because both were suppressed by reduced dose of Spir. Thus, an important role of Lola is to limit expression of Spir to appropriate levels within da neurons. We found Spir to be expressed in dendritic arbors and to be important for their development. Removal of Spir from class IV da neurons reduced F-actin levels and total branch number, shifted the position of greatest branch density away from the cell soma, and compromised nocifensive behavior. We conclude that the Lola-Spir pathway is crucial for the spatial arrangement of branches within dendritic trees and for neural circuit function because it provides balanced control of the F-actin cytoskeleton.
Год издания: 2014
Авторы: Tiago Ferreira, Yimiao Ou, Sally Li, Edward Giniger, Donald J. van Meyel
Издательство: The Company of Biologists
Источник: Development
Ключевые слова: Neurobiology and Insect Physiology Research, Animal Behavior and Reproduction, Plant Molecular Biology Research
Другие ссылки: Development (PDF)
Development (HTML)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
PubMed (HTML)