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STRING v9.1:protein-proteininteraction networks,with increasedcoverage andintegration Andrea FranceschiniDamian SzklarczykSune Pletscher-Frankild2012 год

STRING v9.1: protein-protein interaction networks, with increased coverage and integration
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Аннотация: Complete knowledge of all direct and indirect interactions between proteins in a given cell would represent an important milestone towards a comprehensive description of cellular mechanisms and functions. Although this goal is still elusive, considerable progress has been made—particularly for certain model organisms and functional systems. Currently, protein interactions and associations are annotated at various levels of detail in online resources, ranging from raw data repositories to highly formalized pathway databases. For many applications, a global view of all the available interaction data is desirable, including lower-quality data and/or computational predictions. The STRING database (http://string-db.org/) aims to provide such a global perspective for as many organisms as feasible. Known and predicted associations are scored and integrated, resulting in comprehensive protein networks covering >1100 organisms. Here, we describe the update to version 9.1 of STRING, introducing several improvements: (i) we extend the automated mining of scientific texts for interaction information, to now also include full-text articles; (ii) we entirely re-designed the algorithm for transferring interactions from one model organism to the other; and (iii) we provide users with statistical information on any functional enrichment observed in their networks.
Год издания: 2012
Авторы: Andrea Franceschini, Damian Szklarczyk, Sune Pletscher-Frankild, Michael Kuhn, Milan Simonovic, Alexander Röth, Jianyi Lin, Pablo Mínguez, Peer Bork, Christian von Mering, Lars Juhl Jensen
Издательство: Oxford University Press
Источник: Nucleic Acids Research
Ключевые слова: Bioinformatics and Genomic Networks, Computational Drug Discovery Methods, Microbial Metabolic Engineering and Bioproduction
Другие ссылки: Nucleic Acids Research (HTML)
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