Аннотация:they can appear in the lung, heart, larynx and Achilles tendon [2].Methotrexate nodulosis is rare in patients with rheumatoid arthritis who are negative for rheumatoid factor [3]. Nodules often, but not always, regress or disappear on discontinuing the drug [3].Methotrexate nodulosis in conditions other than rheumatoid arthritis is very rare.It has been reported in a patient with systemic lupus erythematosus and Jaccoud's arthropathy [4], a patient with juvenile arthritis who was rheumatoid factor negative [5], and a patient with psoriatic arthritis and negative rheumatoid factor [6].Only the patient with juvenile arthritis had pulmonary nodules.However, a recent case report describes a patient similar to ours with psoriatic arthritis and negative rheumatoid factor who developed accelerated pulmonary nodulosis and a sterile pleural effusion after treatment with methotrexate [7].Open lung biopsy showed histology compatible with a rheumatoid nodule.The nodules resolved on stopping methotrexate treatment.
