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Prefrontal DopamineD1Receptors andWorking Memory inSchizophrenia Anissa Abi‐DarghamOsama MawlawiIlise Lombardo2002 год

Prefrontal Dopamine D1Receptors and Working Memory in Schizophrenia
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Аннотация: Studies in nonhuman primates documented that appropriate stimulation of dopamine (DA) D1 receptors in the dorsolateral prefrontal cortex (DLPFC) is critical for working memory processing. The defective ability of patients with schizophrenia at working memory tasks is a core feature of this illness. It has been postulated that this impairment relates to a deficiency in mesocortical DA function. In this study, D1 receptor availability was measured with positron emission tomography and the selective D1 receptor antagonist [11C]NNC 112 in 16 patients with schizophrenia (seven drug-naive and nine drug-free patients) and 16 matched healthy controls. [11C]NNC 112 binding potential (BP) was significantly elevated in the DLPFC of patients with schizophrenia (1.63 ± 0.39 ml/gm) compared with control subjects (1.27 ± 0.44 ml/gm; p = 0.02). In patients with schizophrenia, increased DLPFC [11C]NNC 112 BP was a strong predictor of poor performance at the n-back task, a test of working memory. These findings confirm that alteration of DLPFC D1 receptor transmission is involved in working memory deficits presented by patients with schizophrenia. Increased D1 receptor availability observed in patients with schizophrenia might represent a compensatory (but ineffective) upregulation secondary to sustained deficiency in mesocortical DA function.
Год издания: 2002
Авторы: Anissa Abi‐Dargham, Osama Mawlawi, Ilise Lombardo, Roberto Gil, Diana Martínez, Yiyun Huang, Dah‐Ren Hwang, John G. Keilp, Lisa D. Kochan, Ronald Van Heertum, Jack M. Gorman, Marc Laruelle
Издательство: Society for Neuroscience
Источник: Journal of Neuroscience
Ключевые слова: Schizophrenia research and treatment, Functional Brain Connectivity Studies, Neural and Behavioral Psychology Studies
Другие ссылки: Journal of Neuroscience (PDF)
Journal of Neuroscience (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
PubMed (HTML)