Exercise, cognitive function, and agingreview
Аннотация: Increasing the lifespan of a population is often a marker of a country's success. With the percentage of the population over 65 yr of age expanding, managing the health and independence of this population is an ongoing concern. Advancing age is associated with a decrease in cognitive function that ultimately affects quality of life. Understanding potential adverse effects of aging on brain blood flow and cognition may help to determine effective strategies to mitigate these effects on the population. Exercise may be one strategy to prevent or delay cognitive decline. This review describes how aging is associated with cardiovascular disease risks, vascular dysfunction, and increasing Alzheimer's disease pathology. It will also discuss the possible effects of aging on cerebral vascular physiology, cerebral perfusion, and brain atrophy rates. Clinically, these changes will present as reduced cognitive function, neurodegeneration, and the onset of dementia. Regular exercise has been shown to improve cognitive function, and we hypothesize that this occurs through beneficial adaptations in vascular physiology and improved neurovascular coupling. This review highlights the potential interactions and ideas of how the age-associated variables may affect cognition and may be moderated by regular exercise.
Год издания: 2015
Авторы: Jill N. Barnes
Издательство: American Physical Society
Источник: AJP Advances in Physiology Education
Ключевые слова: Neurological Disease Mechanisms and Treatments, Dementia and Cognitive Impairment Research, Cardiovascular Health and Disease Prevention
Другие ссылки: AJP Advances in Physiology Education (PDF)
AJP Advances in Physiology Education (HTML)
PubMed Central (HTML)
Europe PMC (PubMed Central) (HTML)
PubMed (HTML)
AJP Advances in Physiology Education (HTML)
PubMed Central (HTML)
Europe PMC (PubMed Central) (HTML)
PubMed (HTML)
Открытый доступ: bronze
Том: 39
Выпуск: 2
Страницы: 55–62