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EpidemiologicClassification ofHuman PapillomavirusTypes Associated withCervical Cancer Núbia MuñózF. Xavier BoschSílvia de Sanjosé2003 год

Epidemiologic Classification of Human Papillomavirus Types Associated with Cervical Cancer
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Аннотация: Infection with human papilloma virus (HPV) is the main cause of cervical cancer, but the risk associated with the various HPV types has not been adequately assessed.We pooled data from 11 case-control studies from nine countries involving 1918 women with histologically confirmed squamous-cell cervical cancer and 1928 control women. A common protocol and questionnaire were used. Information on risk factors was obtained by personal interviews, and cervical cells were collected for detection of HPV DNA and typing in a central laboratory by polymerase-chain-reaction-based assays (with MY09/MY11 and GP5+/6+ primers).HPV DNA was detected in 1739 of the 1918 patients with cervical cancer (90.7 percent) and in 259 of the 1928 control women (13.4 percent). With the GP5+/6+ primer, HPV DNA was detected in 96.6 percent of the patients and 15.6 percent of the controls. The most common HPV types in patients, in descending order of frequency, were types 16, 18, 45, 31, 33, 52, 58, and 35. Among control women, types 16, 18, 45, 31, 6, 58, 35, and 33 were the most common. For studies using the GP5+/6+ primer, the pooled odds ratio for cervical cancer associated with the presence of any HPV was 158.2 (95 percent confidence interval, 113.4 to 220.6). The odds ratios were over 45 for the most common and least common HPV types. Fifteen HPV types were classified as high-risk types (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73, and 82); 3 were classified as probable high-risk types (26, 53, and 66); and 12 were classified as low-risk types (6, 11, 40, 42, 43, 44, 54, 61, 70, 72, 81, and CP6108). There was good agreement between our epidemiologic classification and the classification based on phylogenetic grouping.In addition to HPV types 16 and 18, types 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73, and 82 should be considered carcinogenic, or high-risk, types, and types 26, 53, and 66 should be considered probably carcinogenic.
Год издания: 2003
Авторы: Núbia Muñóz, F. Xavier Bosch, Sílvia de Sanjosé, Rolando Herrero, Xavier Castellsagué, Keerti V. Shah, Peter J.F. Snijders, Chris J.L.M. Meijer
Издательство: Massachusetts Medical Society
Источник: New England Journal of Medicine
Ключевые слова: Cervical Cancer and HPV Research, Genital Health and Disease, Hepatitis B Virus Studies
Другие ссылки: New England Journal of Medicine (PDF)
New England Journal of Medicine (HTML)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (PDF)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (HTML)
Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (PDF)
Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (HTML)
PubMed (HTML)