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Adverse Effects ofTestosterone Therapyin Adult Men: ASystematic Review andMeta-Analysis Mercè Fernández-BalsellsM. Hassan MuradMelanie A. Lane2010 год

Adverse Effects of Testosterone Therapy in Adult Men: A Systematic Review and Meta-Analysis
review

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: The risks of testosterone therapy in men remain poorly understood.The aim of this study was to conduct a systematic review and meta-analyses of testosterone trials to evaluate the adverse effects of testosterone treatment in men.We searched MEDLINE, EMBASE, and Cochrane CENTRAL from 2003 through August 2008. Review of reference lists and contact with experts further identified candidate studies.Eligible studies were comparative, randomized, and nonrandomized and reported the effects of testosterone on outcomes of interest (death, cardiovascular events and risk factors, prostate outcomes, and erythrocytosis). Reviewers, working independently and in duplicate, determined study eligibility.Reviewers working independently and in duplicate determined the methodological quality of studies and collected descriptive, quality, and outcome data.The methodological quality of the 51 included studies varied from low to medium, and follow-up duration ranged from 3 months to 3 yr. Testosterone treatment was associated with a significant increase in hemoglobin [weighted mean difference (WMD), 0.80 g/dl; 95% confidence interval (CI), 0.45 to 1.14] and hematocrit (WMD, 3.18%; 95% CI, 1.35 to 5.01), and a decrease in high-density lipoprotein cholesterol (WMD, -0.49 mg/dl; 95% CI, -0.85 to -0.13). There was no significant effect on mortality, prostate, or cardiovascular outcomes.The adverse effects of testosterone therapy include an increase in hemoglobin and hematocrit and a small decrease in high-density lipoprotein cholesterol. These findings are of unknown clinical significance. Current evidence about the safety of testosterone treatment in men in terms of patient-important outcomes is of low quality and is hampered by the brief study follow-up.
Год издания: 2010
Авторы: Mercè Fernández-Balsells, M. Hassan Murad, Melanie A. Lane, Juliana F. Lampropulos, Felipe N. Albuquerque, Rebecca J. Mullan, Neera Agrwal, Mohamed B. Elamin, Juan F. Gallegos‐Orozco, Amy T. Wang, Patricia J. Erwin, Shalender Bhasin, Víctor M. Montori
Издательство: Oxford University Press
Источник: The Journal of Clinical Endocrinology & Metabolism
Ключевые слова: Hormonal and reproductive studies, Doping in Sports, Sexual Differentiation and Disorders
Другие ссылки: The Journal of Clinical Endocrinology & Metabolism (PDF)
The Journal of Clinical Endocrinology & Metabolism (HTML)
PubMed (HTML)