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Imaging of integrinαvβ3 expression inpatients withmalignant glioma by[18F] Galacto-RGDpositron emissiontomography Oliver SchnellBjarne KrebsJanette Carlsen2009 год

Imaging of integrin αvβ3 expression in patients with malignant glioma by [18F] Galacto-RGD positron emission tomography
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Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Inhibitors targeting the integrin alpha(v)beta(3) are promising new agents currently tested in clinical trials for supplemental therapy of glioblastoma multiforme (GBM). The aim of our study was to evaluate (18)F-labeled glycosylated Arg-Gly-Asp peptide ([(18)F]Galacto-RGD) PET for noninvasive imaging of alpha(v)beta(3) expression in patients with GBM, suggesting eligibility for this kind of additional treatment. Patients with suspected or recurrent GBM were examined with [(18)F]Galacto-RGD PET. Standardized uptake values (SUVs) of tumor hotspots, galea, and blood pool were derived by region-of-interest analysis. [(18)F]Galacto-RGD PET images were fused with cranial MR images for image-guided surgery. Tumor samples taken from areas with intense tracer accumulation in the [(18)F]Galacto-RGD PET images and were analyzed histologically and immunohistochemically for alpha(v)beta(3) integrin expression. While normal brain tissue did not show significant tracer accumulation (mean SUV, 0.09 +/- 0.04), GBMs demonstrated significant but heterogeneous tracer uptake, with a maximum in the highly proliferating and infiltrating areas of tumors (mean SUV, 1.6 +/- 0.5). Immunohistochemical staining was prominent in tumor microvessels as well as glial tumor cells. In areas of highly proliferating glial tumor cells, tracer uptake (SUVs) in the [(18)F]Galacto-RGD PET images correlated with immunohistochemical alpha(v)beta(3) integrin expression of corresponding tumor samples. These data suggest that [(18)F] Galacto-RGD PET successfully identifies alpha(v)beta(3) expression in patients with GBM and might be a promising tool for planning and monitoring individualized cancer therapies targeting this integrin.
Год издания: 2009
Авторы: Oliver Schnell, Bjarne Krebs, Janette Carlsen, Isabelle Miederer, Claudia Goetz, Roland Goldbrunner, Hans‐Jürgen Wester, Roland Haubner, Gabriele Pöpperl, Markus Holtmannspötter, Hans A. Kretzschmar, Horst Kessler, Jörg-Christian Tonn, Markus Schwaiger, Ambros J. Beer
Издательство: Oxford University Press
Источник: Neuro-Oncology
Ключевые слова: Cell Adhesion Molecules Research, Barrier Structure and Function Studies, Caveolin-1 and cellular processes
Другие ссылки: Neuro-Oncology (PDF)
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Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
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