Quantitative Relationships Between Circulating Leukocytes and Infection in Patients with Acute Leukemiaстатья из журнала
Аннотация: Article1 February 1966Quantitative Relationships Between Circulating Leukocytes and Infection in Patients with Acute LeukemiaGERALD P. BODEY, M.D., MONICA BUCKLEY, B.A., Y. S. SATHE, PH.D., EMIL J FREIREICH, M.D.GERALD P. BODEY, M.D., MONICA BUCKLEY, B.A., Y. S. SATHE, PH.D., EMIL J FREIREICH, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-2-328 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptInfection is currently the major fatal complication of acute leukemia (1). Previous studies have indicated a relationship between leukopenia and the presence of infection in patients with acute leukemia (2-4) and various types of agranulocytosis (5-7). Chemotherapeutic agents with bone marrow toxicity are being used with increasing frequency in malignant and other chronic diseases. Also, a high incidence of infection has accompanied the use of these agents as immunosuppressive therapy in patients receiving organ transplantation (8). The present study examines the quantitative relationships between the presence of infection and the degree and duration of leukopenia in patients with acute leukemia....References1. HERSHBODEYNIESFREIREICH EMGPBAEJ: The causes of death in acute leukemia. A study of 414 patients from 1954-1963. JAMA 193: 105, 1965. CrossrefMedlineGoogle Scholar2. MILLERSHANBROM SPE: Infectious syndromes of leukemias and lymphomas. Amer. J. Med. Sci. 246: 420, 1963. CrossrefMedlineGoogle Scholar3. SILVERBEALSCHNEIDERMANMCCULLOUGH RTGAMANB: The role of the mature neutrophil in bacterial infections in acute leukemia. Blood 12: 814, 1957. CrossrefMedlineGoogle Scholar4. BAKER RD: Leukopenia and therapy in leukemia as factors predisposing to fatal mycoses. Mucormycosis, aspergillosis, and cryptococcosis. Amer. J. Clin. Path. 37: 358, 1962. CrossrefMedlineGoogle Scholar5. BROWNEMARCUS EAAJ: Chronic idiopathic neutropenia. New Eng. J. Med. 262: 795, 1960. CrossrefMedlineGoogle Scholar6. KOSTMANN R: Infantile genetic agranulocytosis. Acta Paediat. (Stockholm) (Supplement 105) 45: 1, 1956. MedlineGoogle Scholar7. SPAETDAMESHEK THW: Chronic hypoplastic neutropenia. Amer. J. Med. 13: 35, 1952. CrossrefMedlineGoogle Scholar8. HILLROLLAROWLANDSRIFKIND JBDTD: Infectious pulmonary disease in patients receiving immunosuppressive therapy for organ transplantation. New Eng. J. Med. 271: 1021, 1964. CrossrefMedlineGoogle Scholar9. FREIKARONLEVINFREIREICHTAYLORHANANIANSELAWRYHOLLANDHOOGSTRATENWOLMANABIRSAWITSKYLEEMILLSBURGERTSPURRPATTERSONEBAUGHJAMESMOON EMRHEJRJJOJFBIJEASSDEOCLRBFGGWJH: Effectiveness of combinations of antileukemic agents in inducing and maintaining remission in children with acute leukemia. In press. Google Scholar10. LEVINHENDERSONKARONFREIREICH RHEMEJ: Treatment of acute leukemia with methylglyoxal-bis-guanylhydrazone (Methyl GAG). Clin. Pharmacol. Ther. 6: 31, 1965. CrossrefMedlineGoogle Scholar11. RICHARBREAKELL WJES: Evaluation of an electronic particle counter for the counting of white blood cells. Amer. J. Clin. Path. 31: 384, 1959. CrossrefMedlineGoogle Scholar12. BISEL HF: Criteria for the evaluation of response to treatment in acute leukemia. Blood 11: 676, 1956. Google Scholar13. WINTROBE MM: Clinical Hematology, 5th ed. Lea & Febiger, Philadelphia, 1961, p. 254. Google Scholar14. MCFARLANDLEBRE WEP: Abnormal leukocyte response in alcoholism. Ann. Intern. Med. 59: 865, 1963. LinkGoogle Scholar15. BOGGSWINTROBECARTWRIGHT DRMGE: The acute leukemias. Analysis of 322 cases and review of the literature. Medicine (Balt.) 41: 163, 1962. CrossrefMedlineGoogle Scholar16. BOGGSFREI DRE: Clinical studies of fever and infection in cancer. Cancer 13: 1240, 1960. CrossrefGoogle Scholar17. HERSHCARBONEWONGFREIREICH EMPPVGEJ: Inhibition of the primary immune response in man by antimetabolites. Cancer Res. In press. Google Scholar18. JAFFE RH: Morphology of the inflammatory defense reactions in leukemia. Arch. Path. (Chicago) 14: 177, 1932. Google Scholar19. BRAUDEFELTESBROOKS AIJM: Differences between the activities of mature granulocytes in leukemic and normal blood. J. Clin. Invest. 33: 1036, 1954. CrossrefMedlineGoogle Scholar20. BOGGS DR: The cellular composition of inflammatory exudates in human leukemias. Blood 15: 466, 1960. CrossrefMedlineGoogle Scholar21. PERILLIEFINCH PEC: The local exudative cellular response in leukemia. J. Clin. Invest. 39: 1353, 1960. CrossrefMedlineGoogle Scholar22. PERILLIEFINCH PESC: Quantitative studies of the local exudative cellular reaction in acute leukemia. J. Clin. Invest. 43: 425, 1964. CrossrefMedlineGoogle Scholar23. PAGEGOOD ARRA: A clinical and experimental study of the function of neutrophils in the inflammatory response. Amer. J. Path. 34: 645, 1958. MedlineGoogle Scholar24. RAABHOEPRICHWINTROBECARTWRIGHT SOPDMMGE: The clinical significance of fever in acute leukemia. Blood 16: 1609, 1960. CrossrefMedlineGoogle Scholar25. MILLER CP: The effect of irradiation on natural resistance to infection. Ann. N. Y. Acad. Sci. 66: 280, 1956. CrossrefGoogle Scholar26. DERBYROGERS BMDE: Studies on bacteremia. V. The effect of simultaneous leukopenia and reticuloendothelial blockade on the early blood stream clearance of staphylococci and Escherichia coli. J. Exp. Med. 113: 1053, 1961. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, MarylandFrom the Medicine Branch, Leukemia Service, and the Mathematical and Statistics and Applied Mathematical Section, National Cancer Institute, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to Gerald P. Bodey, M.D., Building 10, Room 2B45, National Institutes of Health, Bethesda, Md. 20014. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAssociation Between Lymphopenia at 1 Month Posttransplant and Infectious Outcomes or Death in Heart Transplant RecipientsPredicting fever in neutropenia with safety‐relevant events in children undergoing chemotherapy for cancer: The prospective multicenter SPOG 2015 FN Definition StudyEmergency management of fever and neutropenia in children with cancer: A reviewDe novo adult acute myeloid leukemia with two new mutations in juxtatransmembrane domain of the FLT3 gene: a case reportCytomegalovirus reactivation in esophageal cancer patients receiving chemoradiotherapy: A retrospective analysisAssessing febrile neutropenia outcomes in patients receiving primary versus secondary prophylactic G-CSF treatment therapy with intermediate neutropenic risk chemotherapy regimensModelling and Simulation of the Effect of Targeted Decolonisation on Incidence of Extended-Spectrum Beta-Lactamase-Producing Enterobacterales Bloodstream Infections in Haematological PatientsThe impact of granulocyte colony stimulating factor on patients receiving chimeric antigen receptor T ‐cell therapyRetrospective comparison of reinfusion procedures and subsequent leukopenia in autologous stem cell transplantationCharacteristics, risk factors, and outcomes of neutropenia after liver or kidney transplantation in childrenHistory of whole pelvis plus para-aortic radiation is a risk factor associated with febrile neutropenia during chemotherapy for recurrent cervical cancerManagement of the Older Patient with Myelodysplastic SyndromeAssociation between the dietary regimen and infection-related complications in neutropenic high-risk patients with cancerGranulocyte transfusions in haematopoietic cell transplants and leukaemia: the phoenix or beating a dead horse?D‐index as a marker of bloodstream infections in patients with allogeneic hematopoietic stem cell transplantationFactors associated with neutropenia post heart transplantationAssociation of an emergency department febrile neutropenia intervention protocol with time to initial antibiotic treatmentPseudoneutropenia as a factor-limiting access to chemotherapy for cancer patients: the effect of a simple mealManagement of bacterial and fungal infections in cirrhosis: The MDRO challengeChest CT Has Higher Yield for Infection than CT Sinus in Febrile Neutropenic PatientsTherapeutic granulocyte infusion for patients with severe neutropaenia and neutrophilic dysfunction: New Zealand experienceTissue Damage in Radiation-Induced Oral Mucositis Is Mitigated by IL-17 Receptor SignalingFungal Infections of the Gastrointestinal TractAn Analysis of the Infections and Determination of Empiric Antibiotic Therapy in Cats and Dogs with Cancer-Associated InfectionsTrilaciclib prior to chemotherapy and atezolizumab in patients with newly diagnosed extensive‐stage small cell lung cancer: A multicentre, randomised, double‐blind, placebo‐controlled Phase II trialIncidence and predictive risk factors of neutropenic sepsis in post-chemotherapy febrile patients in emergency department: A single-center retrospective longitudinal studyInfectious Morbidity in Pediatric Patients Receiving Neoadjuvant Chemotherapy for SarcomaA place for neutrophils in the beneficial pathogen-agnostic effects of the BCG vaccineUnderstanding and Managing Sepsis in Patients With Cancer in the Era of Antimicrobial ResistanceImmune‐related adverse events of a PD‐L1 inhibitor plus chemotherapy versus a PD‐L1 inhibitor alone in first‐line treatment for advanced non–small cell lung cancer: A meta‐analysis of randomized control trialsCarbapenem-Resistant Enterobacteriaceae—Implications for Treating Acute Leukemias, a Subgroup of Hematological MalignanciesNetwork mapping of primary CD34+ cells by Ampliseq based whole transcriptome targeted resequencing identifies unexplored differentiation regulatory relationshipsAlternative pneumocystis prophylaxis in solid organ transplant recipients at two large transplant centersFebrile Neutropenia: Decreasing Time to Antibiotic Administration in a Community Hospital Emergency DepartmentBenign ethnic neutropenia in a South African population, and its association with HIV acquisition and adverse event reporting in an HIV vaccine clinical trialCitrulline as a biomarker of bacteraemia during induction treatment for childhood acute lymphoblastic leukaemiaManagement of Infections in Neutropenic PatientsAntibacterial and Antiparasitic ProphylaxisFebrile NeutropeniaMyelopreservation with Trilaciclib in Patients Receiving Topotecan for Small Cell Lung Cancer: Results from a Randomized, Double-Blind, Placebo-Controlled Phase II StudyForewordManagement principles for patients with neutropeniaStress-buffering effect of social support on immunity and infectious risk during chemotherapy for breast cancerThe clinical profile, management, and outcome of febrile neutropenia in acute myeloid leukemia from resource constraint settingsThe Impact of Modifying Empirical Antibiotic Therapy Based on Intestinal Colonization Status on Clinical Outcomes of Febrile Neutropenic PatientsComparison of the etiologic, microbiologic, clinical and outcome characteristics of febrile vs. non-febrile neutropenia in hospitalized immunocompetent childrenComplete, yet partial: the benefits of complete response with partial haematological recovery as an endpoint in acute myeloid leukaemia clinical trialsAssessment of infection in newly diagnosed multiple myeloma patients: risk factors and main characteristicsSmoking is associated with pneumonia development in lung cancer patientsEfficacy and safety of oral magnesium supplementation in reducing febrile neutropenia episodes in children with solid tumors treated with cisplatin-based chemotherapy: randomized clinical trialInfection at diagnosis—a unique challenge in acute myeloid leukemia treatment in developing worldUtility of procalcitonin as a predictor of bloodstream infections and supportive modality requirements in critically ill cancer patientsAssessing Needs and Experiences of Preparing for Medical Emergencies Among Children With Cancer and Their CaregiversPossibilities of supportive therapy in patients with blood system tumors and malignant neoplasmsHigh Burden of Serious Bacterial Infections in African Children Treated for CancerEfficacy and safety of granulocyte transfusion in children: A single‐center experienceEvaluation of a 0.75 × 10 9 /L absolute neutrophil count cut‐off for antimicrobial prophylaxis in canine cancer chemotherapy patientsInfectious disease considerations in immunocompromised patientsRectal colonization with multidrug-resistant gram-negative bacteria in patients with hematological malignancies: a prospective studyThe Feasibility of Host Transcriptome Profiling as a Diagnostic Tool for Microbial Etiology in Childhood Cancer Patients with Febrile NeutropeniaAn in vitro quantitative systems pharmacology approach for deconvolving mechanisms of drug-induced, multilineage cytopeniasPersonalized cancer supportive care in COVID-19 eraAssociation Between Depth of Neutropenia and Clinical Outcomes in Febrile Pediatric Cancer and/or Patients Undergoing Hematopoietic Stem-cell TransplantationPrediction of Survival Benefit of Filgrastim in Adult and Pediatric Patients With Acute Radiation SyndromeEvaluation of the HemoCue WBC DIFF in leukopenic patient samplesAge‐related prevalence and clinical significance of neutropenia ‐ isolated or combined with other cytopenias: Real world data from 373 820 primary care individualsInterventions aiming to reduce time to antibiotics (TTA) in patients with fever and neutropenia during chemotherapy for cancer (FN), a systematic reviewPreoperative Nutritional Status Contributes to the Development of Neutropenia Event in Patients With Gastric Cancer Receiving CAPEOX Adjuvant ChemotherapyThe cost of a “benign” condition: Healthcare utilization and infectious outcomes in young children with primary autoimmune neutropeniaComparison of two different anti-infectious approaches after high-dose chemotherapy and autologous stem cell transplantation for hematologic malignancies in a 12-year period in British Hospital, UruguayIn canine bacterial pneumonia circulating granulocyte counts determine outcome from donor cellsD-Index–Guided Early Antifungal Therapy Versus Empiric Antifungal Therapy for Persistent Febrile Neutropenia: A Randomized Controlled Noninferiority TrialProphylaxis of febrile neutropenia with colony-stimulating factors: the first 25 yearsNeutropenia management in patients receiving myelosuppressive polychemotherapy for early breast cancer in Belgium: BRONS study resultsTranscriptional regulation of neutrophil differentiation and function during inflammationAssociation of time to antibiotics and clinical outcomes in patients with fever and neutropenia during chemotherapy for cancer: a systematic reviewUp-to-Date Infection Control Practices for Febrile Neutropenic PatientsRecent advances and future directions in the management of the immunocompromised hostThe Role of Neutrophils in the Immune System: An OverviewEfficient Bayesian Expert Models for Fever in Neutropenia and Fever in Neutropenia with BacteremiaAntimicrobial Prophylaxis in High-Risk Oncology PatientsInfection in the Patient With Cancer Detection and Control of Biofilm Formation by Staphylococcus aureus from Febrile Neutropenic Patient Protocol for a systematic review of time to antibiotics (TTA) in patients with fever and neutropenia during chemotherapy for cancer (FN) and interventions aiming to reduce TTAEffect of adjunctive corticosteroid on 28-day mortality in neutropenic patients with septic shockImpact of neutropenia on central venous catheter–related bloodstream infections in patients with hematological malignancies at the time of central venous catheter insertion: A matched-pair analysisPeritoneal GATA6+ macrophages function as a portal for Staphylococcus aureus disseminationPhysical Exercise during Radiation and ChemotherapyImpact of preleukemic mutations and their persistence on hematologic recovery after induction chemotherapy for AMLThe clinical management of invasive mold infection in children with cancer or undergoing hematopoietic stem cell transplantationInpatient Health Care Utilization in Children With Hemophilia Before and After the Joint Outcome Study PublicationUse of Growth Factors and Other Cytokines for Treatment of Injuries During a Radiation Public Health EmergencyUse of Growth Factors and Cytokines to Treat Injuries Resulting from a Radiation Public Health EmergencyNonneutropenic fever in children with cancer: A scoping review of management and outcomeHost and Graft Factors Impacting Infection Risk in Hematopoietic Cell TransplantationWork-up for Fever During Neutropenia for Both the Stem Cell Transplant Recipient and the Hematologic Malignancy PatientInappropriate Empirical Antibiotic Treatment in High-risk Neutropenic Patients With Bacteremia in the Era of Multidrug ResistanceOutpatient treatment for people with cancer who develop a low-risk febrile neutropaenic eventRisk factors for extended-spectrum beta-lactamase-producing Enterobacteriaceae infection causing septic shock in cancer patients with chemotherapy-induced febrile neutropeniaCan immune biomarkers predict infections in solid organ transplant recipients? A review of current evidenceManagement of Patients With Fever and Neutropenia Through the Arc of Time A Narrative ReviewPhilip A. Pizzo, MDSTUDY ON HAEMATOLOGICAL PROFILE AMONG HIV POSITIVE PATIENTSThe immune response to fungal challengeNeutrophil Heterogeneity as Therapeutic Opportunity in Immune-Mediated DiseaseSpecific Decrease in B-Cell-Derived Extracellular Vesicles Enhances Post-Chemotherapeutic CD8+ T Cell ResponsesEpisodes of fever in neutropenia in pediatric patients with cancer in Bern, Switzerland, 1993–2012Prospective Evaluation of Multinational Association of Supportive Care in Cancer Risk Index Score for Gynecologic Oncology Patients With Febrile NeutropeniaAIDS-Related Kaposi Sarcoma, Version 2.2019Infections in Allogeneic Stem Cell TransplantationRespiratory Tract Infections: Sinusitis, Bronchitis, and PneumoniaOral Considerations for the Head and Neck Cancer PatientAntimicrobial Prophylaxis in High-Risk Oncology PatientsAntimicrobial Prophylaxis in High-Risk Oncology PatientsNeutropenic SepsisHematopoietic Growth Factors in the Management of Anemia and Febrile NeutropeniaCreation and evaluation of a cancer chemotherapy order review guide for use at a community hospitalOptimal Management of Neutropenic Fever in Patients With CancerFebrile Neutropenia: An Ounce of Prevention or a Pound of CureEffectiveness of filgrastim and polyethylene glycol-filgrastim in the treatment of postchemotherapy neutropenia in children: Phase I clinical trialPediatric patients at risk for fever in chemotherapy-induced neutropenia in Bern, Switzerland, 1993-2012One-year mortality and Periprosthetic infection rates after Total knee Arthroplasty in Cancer patients: a population-based cohort studyClinical confirmation to demonstrate similarity for a biosimilar pegfilgrastim: a 3-way randomized equivalence study for a proposed biosimilar pegfilgrastim versus US-licensed and EU-approved reference products in breast cancer patients receiving myelosuppressive chemotherapyCost-effectiveness analysis of lipegfilgrastim as primary prophylaxis in women with breast cancer in Australia: a modelled economic evaluationThe Lung Microvasculature Is a Functional Immune NicheLeukopenia and lack of ribavirin predict poor outcomes in patients with haematological malignancies and respiratory syncytial virus infectionInfectious complications in patients with acute leukemia according to the duration of neutropeniaAntimicrobial Prophylaxis for Adult Patients With Cancer-Related Immunosuppression: ASCO and IDSA Clinical Practice Guideline UpdateExtended vs Bolus Infusion of Broad-Spectrum β-Lactams for Febrile Neutropenia: An Unblinded, Randomized TrialAssociations between neutrophil recovery time, infections and relapse in pediatric acute myeloid leukemiaA cohort study on protocol-based nurse-led out-patient management of post-chemotherapy low-risk febrile neutropeniaPulmonary Infections in Immunocompromised HostsAntibiotic prophylaxis in veterinary cancer chemotherapy: A review and recommendationsPrescribing Empiric Antibiotics for Febrile Neutropenia: Compliance with Institutional Febrile Neutropenia GuidelinesCharacteristics and Clinical Outcomes of Critically Ill Cancer Patients Admitted to Korean Intensive Care UnitsTissue macrophages as mediators of a healthy relationship with gut commensal microbiotaDrug-Induced Hematological Cytopenia in Kidney Transplantation and the Challenges It Poses for Kidney Transplant PhysiciansThe Infectious and Noninfectious Etiology, Clinical Picture and Outcome of Neutropenia in Immunocompetent Hospitalized ChildrenFully reduced HMGB1 accelerates the regeneration of multiple tissues by transitioning stem cells to G AlertPredictors of chemoradiation related febrile neutropenia prophylaxis in older adults – Experience from a limited resource settingReduced Neutrophil Elastase Activity and Neutrophil Extracellular Traps in Pediatric Acute Myeloid Leukemia May Increase the Rate of InfectionsNeutropenia in pediatric heart transplant recipientsClinicohematological profile of febrile neutropenia in childhood acute leukemia and utility of serum procalcitonin levels in neutropenic patientsHost Control of Fungal Infections: Lessons from Basic Studies and Human CohortsNatural killer cells as a therapeutic tool for infectious diseases - current status and future perspectivesThe enigmatic neutrophil: what we do not knowRadionuclide Imaging of Infection and Inflammation in Children: a ReviewRethinking Antimicrobial Prophylaxis in the Transplant Patient in the World of Emerging Resistant Organisms—Where Are We Today?Granulocyte transfusions in the management of neutropenic fever: A pediatric perspectiveSEIFEM 2017: from real life to an agreement on the use of granulocyte transfusions and colony-stimulating factors for prophylaxis and treatment of infectious complications in patients with hematologic malignant disordersA randomized trial of the effectiveness of the neutropenic diet versus food safety guidelines on infection rate in pediatric oncology patientsNeutropenic SepsisSupportive Care for Patients with Leukemia: A Historical PerspectiveInfections in CancerInfections and CancerFever and GranulocytopeniaOncologic EmergenciesManagement and cost analysis of cancer patients treated with G-CSF: a cohort study based on the French national healthcare insurance databaseImpact of chemotherapy-induced neutropenia (CIN) and febrile neutropenia (FN) on cancer treatment outcomes: An overview about well-established and recently emerging clinical dataNeutropenic FeverMultidrug-resistant Enterobacteriaceae, Pseudomonas aeruginosa , and vancomycin-resistant Enterococcus : Three major threats to hematopoietic stem cell transplant recipientsHealthcare utilization and spending by children with cancer on MedicaidRisk factors for thiopurine-induced myelosuppression and infections in inflammatory bowel disease patients with a normal TPMT genotypePotential for Monitoring Gut Microbiota for Diagnosing Infections and Graft-versus-Host Disease in Cancer and Stem Cell Transplant PatientsMyelosuppression, Bone Disease, and Acute Renal Failure: Evidence-Based Recommendations for Oncologic EmergenciesCost-Utility Analysis of Lipegfilgrastim Compared to Pegfilgrastim for the Prophylaxis of Chemotherapy-Induced Neutropenia in Patients with Stage II-IV Breast CancerDefining a therapeutic window for kinase inhibitors in leukemia to avoid neutropeniaThe effectiveness and safety of same-day versus next-day administration of long-acting granulocyte colony-stimulating factors for the prophylaxis of chemotherapy-induced neutropenia: a systematic reviewA demonstration of analytical similarity comparing a proposed biosimilar pegfilgrastim and reference pegfilgrastimCuantificación de citoquinas y su relación con la presencia de bacteriemia en leucemias agudas y neutropenia febril postquimioterapiaMonocyte nadir is a possible indicator for neutrophil nadir during lung cancer chemotherapyHarnessing Neutrophil Survival Mechanisms during Chronic Infection by Pseudomonas aeruginosa: Novel Therapeutic Targets to Dampen Inflammation in Cystic FibrosisEpic Immune Battles of History: Neutrophils vs. Staphylococcus aureusTherapeutic Use of Filgrastim for Established Febrile Neutropenia Is Cost Effective Among Patients With Solid Tumors and LymphomasIndwelling Pleural Catheters for Patients with Hematologic Malignancies. A 14-Year, Single-Center ExperienceRisk factors and impact of Clostridium difficile recurrence on haematology patientsGranulocyte transfusions in the management of invasive fungal infectionsThe lung is a host defense niche for immediate neutrophil-mediated vascular protectionProphylactic Measures During Induction for Acute Myeloid LeukemiaHematologic Complications and Blood Bank SupportOncologic EmergenciesSKIN, OROPHARYNGEAL AND RESPIRATORY TRACT INFECTIONS IN PATIENTS WITH ACUTE LEUKAEMIA RECEIVING CHEMOTHERAPYIs parenteral chemotherapy safe in rural hospitals? A prospective audit of neutropenic fever in Albany Hospital, a regional West Australian cancer centreCLINICAL PROFILE AND OUTCOME OF FEBRILE NEUTROPENIC CANCER PATIENTS IN A TERTIARY CARE CENTREImmunotherapy of Invasive Fungal DiseaseNeutropeniaInfections in the Cancer PatientProperdin Levels in Individuals with Chemotherapy-Induced NeutropeniaRelease of Danger-Associated Molecular Patterns following Chemotherapy Does Not Induce Immunoparalysis in Leukemia PatientsApplying Multinational Association of Supportive Care of Cancer Index Score for Identifying Febrile Neutropenia Patients at High Risk of Complications at Tertiary Care Hospital, PakistanPost-liver transplant myeloid maturation arrestThe Emergency Care of Patients With Cancer: Setting the Research AgendaEvaluation of Mannose-Binding Lectin is a Useful Approach to Predict the Risk of Infectious Complications Following Autologous Hematopoietic Stem Cell TransplantationClinical relevance of molecular identification of microorganisms and detection of antimicrobial resistance genes in bloodstream infections of paediatric cancer patientsCFTR targeting during activation of human neutrophilsOutcome of severe infections in afebrile neutropenic cancer patientsStaphylococcus aureus : the current state of disease, pathophysiology and strategies for preventionDrug-related genetic polymorphisms affecting severe chemotherapy-induced neutropenia in breast cancer patientsShorter Remission Telomere Length Predicts Delayed Neutrophil Recovery After Acute Myeloid Leukemia Therapy: A Report From the Children’s Oncology GroupAnalysis of overall survival in a large multiethnic cohort reveals absolute neutrophil count of 1,100 as a novel prognostic cutoff in African AmericansExogenous remodeling of lung resident macrophages protects against infectious consequences of bone marrow-suppressive chemotherapyGranulocyte transfusions in critically ill children with prolonged neutropenia: side effects and survival rates from a single-center analysisRelationship between severity and duration of chemotherapy-induced neutropenia and risk of infection among patients with nonmyeloid malignanciesClinical prognostic factors for time to positivity in cancer patients with bloodstream infectionsStaphylococcus aureus Pathogenesis and Virulence Factor RegulationChemotherapy-induced neutropenia among pediatric cancer patients in Egypt: Risks and consequencesOverview of Infections in the Immunocompromised HostTherapeutic Potential of Polyphenols from Epilobium Angustifolium (Fireweed)A randomized, double‐blind trial of pegfilgrastim versus filgrastim for the management of neutropenia during CHASE (R) chemotherapy for malignant lymphomaA clinical evaluation of efficacy and safety of cefepime monotherapy versus piperacillin-tazobactam in patients of paediatric age group with febrile neutropenia in a tertiary care centre of north IndiaPreoperative chemotherapy and corticosteroids: independent predictors of cranial surgical-site infectionsIncreased use of antimicrobial medication in bulimia nervosa and binge-eating disorder prior to the eating disorder treatmentClinical safety of tbo-filgrastim, a short-acting human granulocyte colony-stimulating factorPrédiction de la gravité des neutropénies fébriles par le score de MASCC : une étude de cohorte rétrospectiveNeutrophil left shift and white blood cell count as markers of bacterial infectionPrevalence and clinical significance of neutropenia discovered in routine complete blood cell counts: a longitudinal studyPreventing Infections in Children with CancerCharacteristics of Children With Cancer Discharged or Admitted From the Emergency DepartmentFrequent Emergency Department Utilizers Among Children with CancerOverview of Infections in the Immunocompromised HostEmerging agents for the prevention of treatment induced neutropenia in adult cancer patientsTrajectory of absolute neutrophil counts in patients treated with pegfilgrastim on the day of chemotherapy versus the day after chemotherapyA Randomized Multicenter Phase III Study of Single Administration of Mecapegfilgrastim (HHPG-19K), a Pegfilgrastim Biosimilar, for Prophylaxis of Chemotherapy-Induced Neutropenia in Patients With Advanced Non–Small-Cell Lung Cancer (NSCLC)A Validated Method for Identifying Unplanned Pediatric ReadmissionVery early discharge versus early discharge versus non-early discharge in children with ca
Год издания: 1966
Авторы: Gerald P. Bodey
Издательство: American College of Physicians
Источник: Annals of Internal Medicine
Ключевые слова: Blood disorders and treatments, Neutropenia and Cancer Infections, Acute Myeloid Leukemia Research
Другие ссылки: Annals of Internal Medicine (HTML)
PubMed (HTML)
PubMed (HTML)
Открытый доступ: closed
Том: 64
Выпуск: 2
Страницы: 328–328