Аннотация:Summary The mammalian testis serves two main functions: production of spermatozoa and synthesis of steroids, among them oestrogens are the end products obtained from the irreversible transformation of androgens by aromatase (P450arom). Up today P450arom has been demonstrated in male germ cells of all mammals so far studied (mice, rat, bank vole, bear, monkey). In man Leydig cells and immature germ cells as well as ejaculated spermatozoa express a biologically active aromatase. Moreover germ cells and spermatozoa contain oestrogen receptors (ER‐ α and ER‐ β ) and it is of note that a truncated form of ER‐ α is present in spermatozoa. These observations clearly suggest that oestrogens are likely concerned in various stages of male germ cell development.
Ключевые слова:Sperm and Testicular Function, Estrogen and related hormone effects, Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
